Nature Reviews Neuroscience: April 10, 2013 A study with low statistical power has a reduced chance of detecting a true effect, but it is less well appreciated that low power also reduces the likelihood that a statistically significant result reflects a true effect. Here, we show that the average statistical power of studies in the […]
Stroke: March 7, 2013 Background and Purpose—Restorative therapies have the potential to improve function and reduce disability after stroke with a wide therapeutic window. The current study evaluated GSK249320, a monoclonal antibody that blocks the axon outgrowth inhibition molecule myelin-associated glycoprotein and also protects oligodendrocytes. Methods—Patients with mild-moderate stroke were randomized to intravenous GSK249320 (1, […]
AHA Stroke: April 18, 2013 The global burden of stroke on patients, their relatives, health systems, and the economies that support them is tremendous. In an unprecedented move, the World Health Organization (WHO) and the United Nations have responded to this challenge by declaring the fight against stroke a top pri- ority in their drive to […]
STROKEAHA: April 18, 2013 Background and Purpose—We aimed to evaluate safety and tolerability of a novel operator-independent ultrasound device among stroke-free volunteers. Methods—A headframe containing 18 ultrasound transducers (each operating at 2 MHz, pulsed-wave) was used to expose both temporal windows and the suboccipital window. Read more
Eur Heart J: April 16, 2013 Aims Digoxin is recommended for long-term rate control in paroxysmal, persistent, and permanent atrial fibrillation (AF). While some analyses suggest an association of digoxin with a higher mortality in AF, the intrinsic nature of this association has not been examined in propensity-matched cohorts, which is the objective of the current […]
BMC Cardiovascular Disorders: April 15, 2013 Background Few data on the thromboembolic (TE) risk of paroxysmal and persistent atrial fibrillation (AF) are available. This study aimed to assess the incidence of TE events in paroxysmal and persistent AF. Methods We performed a subset post hoc analysis of 771 patients with paroxysmal and 463 with persistent […]
AHA Stroke: April 11, 2013 Stroke is the fourth leading cause of death in the United States, and it is a major cause of long-term disabil- ity and reduced quality of life for hundreds of thousands of Americans. Over the past decades, teams of National Institute of Neurological Disorders and Stroke (NINDS)–funded clini- cal trialists have […]
Trials: April 11, 2013 Background Traditionally in acute stroke clinical trials, the primary clinical outcome employed is a dichotomized modified Rankin Scale (mRS). New statistical methods, such as responder analysis, are being used in stroke studies to address the concern that baseline prognostic variables, such as stroke severity, impact the likelihood of a successful outcome. Responder […]
CIRCULATIONAHA: April 9, 2013, Background—This study examined the impact of different ablation strategies on AF recurrence and quality of life (QoL) in coexistent atrial fibrillation (AF) and flutter (AFL). Methods and Results—Three-hundred sixty enrolled patients with documented AF and AFL were blinded and randomized to group 1: AF±AFL ablation (n=182) or Group 2: AFL ablation only […]
J NeuroIntervent Surgery: April 6, 2013 Objective There are few data regarding the effect of the Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis (SAMMPRIS) trial results on the management of intracranial atherosclerotic disease (ICAD). We sought to understand the impact of the SAMMPRIS trial on current ICAD clinical practices and future trial […]
