Results of Membrane-activated Chelator Stroke Intervention Randomized Trial of DP-b99 in Acute Ischemic Stroke

​STROKEAHA: February 7, 2013 Background and Purpose—DP-b99, a lipophilic moderate-affinity chelator of zinc, was postulated to improve recovery after acute ischemic stroke. We evaluated the safety and therapeutic effects of DP-b99 in patients with acute hemispheric ischemic stroke. Methods—The Membrane-Activated Chelator Stroke Intervention trial was a randomized, double-blind, placebo-controlled, multicenter, parallel-group trial of intravenous DP-b99 administered […]

Impact of Global Geographic Region on Time in Therapeutic Range on Warfarin Anticoagulant Therapy: Data From the ROCKET AF Clinical Trial

J Am Heart Assoc.: February 19, 2013 Background Vitamin K antagonist (VKA) therapy remains the most common method of stroke prevention in patients with atrial fibrillation. Time in therapeutic range (TTR) is a widely cited measure of the quality of VKA therapy. We sought to identify factors associated with TTR in a large, international clinical trial. Read […]

A Trial of Imaging Selection and Endovascular Treatment for Ischemic Stroke

NEJM: February 8, 2013 BACKGROUND Whether brain imaging can identify patients who are most likely to benefit from therapies for acute ischemic stroke and whether endovascular thrombectomy improves clinical outcomes in such patients remains unclear. Read more

Lower blood pressure targets safe in reducing risk of recurrent stroke

American Heart Association: February 08, 2013 American Stroke Association Late-Breaking Science Report: Abstract LB 8 – Embargoed until 7 a.m. HT/ noon ET on Friday, Feb. 8, 2013 Study Highlights: Survivors of small-artery strokes who lowered their systolic blood pressure below 130 mm Hg were less likely to suffer a hemorrhagic stroke (bleeding in the brain) […]

Delay in breaking up blood clots means worse stroke outcome

American Heart Association: February 08, 2013 American Stroke Association Late-Breaking Science Report: Abstract LB 9 Embargoed until 7 a.m. HT/ noon ET on Friday, Feb. 8, 2013 Study Highlights: In patients who had endovascular therapy added to intravenous clot-busting drugs to restore blood flow after a stroke within seven hours, every 30-minute delay in breaking up […]

Adding clopidogrel to aspirin therapy reduces risk of second stroke

American Heart Association: February 08, 2013 American Stroke Association Late-Breaking Science Report: Abstract LB 11 Embargoed until 7 a.m. HT/ noon ET on Friday, Feb. 8, 2013 Study Highlights: Adding a second drug to aspirin therapy lowered the risk of a second stroke in the weeks after a clot caused minor stroke or TIA in Chinese […]

Endovascular Therapy after Intravenous t-PA versus t-PA Alone for Stroke

NEJM: February 7, 2013 BACKGROUND Endovascular therapy is increasingly used after the administration of intravenous tissue plasminogen activator (t-PA) for patients with moderate-to-severe acute ischemic stroke, but whether a combined approach is more effective than intravenous t-PA alone is uncertain. Read more

Pre-intervention triage incorporating perfusion imaging improves outcomes in patients undergoing endovascular stroke therapy: a comparison with the device trials

J NeuroIntervent Surg: Feb. 18, 2013 Abstract Objectives Endovascular therapy of acute ischemic stroke is evolving towards thrombectomy devices for vessel recanalization. High rates of revascularization have been reported in stroke device trials. However, the discrepancy between recanalization and outcomes raises the question whether patients with irreversible ischemic injury are being exposed to these interventions. This […]

Surgical procedure appears to improve outcomes after bleeding stroke

AHA: February 07, 2013 This news release is featured in a news conference at 7 a.m., HT, Thursday, Feb. 7.  This news release contains updated numbers from the abstract. Study Highlights: A minimally invasive surgery appears safe and may reduce long-term disability after a bleeding stroke. If the findings are confirmed in a larger study, […]

Tai Chi exercise may reduce falls in adult stroke survivors

AHA: February 06, 2013 Study Highlights: Tai Chi exercise reduced falls among stroke survivors. The ancient Chinese martial art helped survivors achieve and maintain balance to aid stroke recovery. HONOLULU, Feb. 6, 2013 — Tai Chi may reduce falls among adult stroke survivors, according to research presented at the American Stroke Association’s International Stroke Conference 2013. […]

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