Clinical Trials
Friday, February 8th, 2013
JACC: February 2013 Objectives This study assessed whether the results of major, potentially practice-altering cardiovascular trials were influenced by the authors’ self-declared financial conflicts of interest (FCOI). Secondary objectives included assessment of trial outcomes by source of funding, by FCOI subtype, and by trial end points. Background Financial conflicts of interest, ubiquitous in cardiovascular medicine because of […]
Clinical Trials
Friday, February 8th, 2013
AHA: February 6, 2013 Background-The impact of apixaban versus aspirin on ischaemic stroke and major bleeding in relation to the CHADS2 and CHA2DS2-VASc stroke risk scores in atrial fibrillation(AF) has not been investigated. Methods and Results-In this secondary analysis of the AVERROES trial, our principal objective was to assess the effect of treatment with aspirin or […]
Clinical Trials
Monday, February 4th, 2013
Hastings Center: January 23, 2013 (Garrison, NY) The longstanding ethical framework for protecting human volunteers in medical research needs to be replaced because it is outdated and can impede efforts to improve health care quality, assert leaders in bioethics, medicine, and health policy in two companion articles in a Hastings Center Report special report, “Ethical Oversight of Learning […]
Clinical Trials
Monday, February 4th, 2013
Clinical Cardiology: January 21, 2013 Background: Warfarin reduces ischemic stroke in atrial fibrillation, but has numerous limitations. Novel oral anticoagulants provide more predictable anticoagulation with fewer shortcomings. Hypothesis: Novel oral anticoagulants are superior to warfarin to prevent stroke or systemic embolism. Methods: Phase III randomized warfarin-controlled trials enrolling >3000 patients that reported clinical efficacy and safety […]
Clinical Trials
Monday, February 4th, 2013
CDC: January 17, 2013 Journals are full of studies of interventions with results that are statistically “significant” but lack guidance on the real importance of the work (1). We suggest that articles concerning clinical or population-health interventions should be accompanied by structured information about the potential health impact. This information should incorporate well-established metrics to expedite […]
Clinical Trials
Monday, February 4th, 2013
JACC: January 1, 2012 Objectives The purpose of this study was to examine the impact of yoga on atrial fibrillation (AF) burden, quality of life (QoL), depression, and anxiety scores. Background Yoga is known to have significant benefit on cardiovascular health. The effect of yoga in reducing AF burden is unknown. Methods This single-center, pre-post study enrolled patients with symptomatic […]
Clinical Trials
Monday, February 4th, 2013
Circulation: December 21, 2012 Background—Pharmacogenetics in warfarin clinical trials have failed to show a significant benefit in comparison with standard clinical therapy. This study demonstrates a computational framework to systematically evaluate preclinical trial design of target population, pharmacogenetic algorithms, and dosing protocols to optimize primary outcomes. Methods and Results—We programmatically created an end-to-end framework that systematically […]
Clinical Trials
Saturday, January 26th, 2013
JACC: January 2013 Objectives This study sought to assess the impact of rhythm- versus rate-control treatment strategies and of underlying rhythm on quality of life and functional capacity in patients with atrial fibrillation (AF) and congestive heart failure (CHF). Background Although intention-to-treat and efficacy analyses have demonstrated similar cardiovascular outcomes in patients with AF and CHF randomized to […]
Clinical Trials
Saturday, January 26th, 2013
Neurology: January 23, 2013 Objectives: We aimed to study the effectiveness of shoulder taping and conventional treatment vs sham taping and conventional treatment in prevention of shoulder injuries in patients with acute stroke. Methods: This study was a multicenter, interventional, prospective, randomized, outcome-blinded trial (PROBE design). All first-ever stroke patients were included within 48 hours of stroke onset […]
Clinical Trials
Saturday, January 26th, 2013
STROKEAHA: January 10, 2013 Background and Purpose—We sought to evaluate the diagnostic accuracy of ultrasound criteria for recanalization during real-time transcranial Doppler monitoring of intra-arterial reperfusion procedures in acute ischemic stroke patients in an international, multicenter study. Methods—Consecutive acute ischemic stroke patients with proximal intracranial occlusions underwent intra-arterial reperfusion procedures with simultaneous real-time transcranial Doppler monitoring […]
