Clinical Trials
Sunday, January 13th, 2013
Ninds.nih.gov: 12/26/12 The NINDS mission is to reduce the burden of neurological disorders through research. Patient studies, including clinical trials that test or compare treatments, can provide important insights for understanding disease, lead to better treatments, and are essential to fulfilling our mission. Many clinical research data sets, however, are only used to address the researchers’ […]
Clinical Trials
Sunday, January 13th, 2013
A Prospective, Multicenter Study JAMA: December 24, 2012 Background The DISCERN AF study (Discerning Symptomatic and Asymptomatic Episodes Pre and Post Radiofrequency Ablation of Atrial Fibrillation) monitored atrial fibrillation (AF) using an implantable cardiac monitor (ICM) to assess the incidence and predictors of asymptomatic AF before and after catheter ablation. Methods Patients with symptomatic AF underwent implantation […]
Clinical Trials
Sunday, January 13th, 2013
American College of Cardiology Foundation: December 1, 2012 Results of the FORWARD (Randomized Trial to Assess Efficacy of PUFA for the Maintenance of Sinus Rhythm in Persistent Atrial Fibrillation) Trial Objectives The aim of this study was to evaluate the efficacy of polyunsaturated fatty acids (n-3 PUFA) for the prevention of recurrent atrial fibrillation (AF) in patients […]
Clinical Trials
Thursday, December 20th, 2012
JAMA: 12/19/12 On November 30, 2010, the regulatory agency for medications in Europe, the European Medicines Agency (EMA), announced a policy on access to “any document originated, received or held by the Agency.”1 The policy made a wide range of regulatory documents potentially accessible to anyone who asks for them, including clinical study reports.2Documents are released […]
Clinical Trials
Thursday, December 20th, 2012
The National Academies Press: 12/19/12 Digital technologies and networks are now part of everyday work in the sciences, and have enhanced access to and use of scientific data, information, and literature significantly. They offer the promise of accelerating the discovery and communication of knowledge, both within the scientific community and in the broader society, as scientific […]
Clinical Trials
Thursday, December 20th, 2012
AHA: 12/18/12 Background and Purpose—Two phase 2 studies of alteplase in acute ischemic stroke 3 to 6 hours after onset, Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET; a randomized, controlled, double-blinded trial), and Diffusion and Perfusion Imaging Evaluation for Understanding Stroke Evolution Study (DEFUSE; open-label, treatment only) using MR imaging-based outcomes have been conducted. We have […]
Clinical Trials
Thursday, December 20th, 2012
AHA: 12/13/12 Background and Purpose—In a substudy of the International Carotid Stenting Study (ICSS), more patients had new ischemic brain lesions on diffusion-weighted magnetic resonance imaging (MRI) after stenting (CAS) than after endarterectomy (CEA). In the present analysis, we compared characteristics of diffusion-weighted MRI lesions. Methods—Number, individual and total volumes, and location of new diffusion-weighted […]
Clinical Trials
Thursday, December 20th, 2012
SAGE: 12/1/12 Background The clinical trials community has a never-ending search for dependable and reliable ways to improve clinical research. This exploration has led to considerable interest in adaptive clinical trial designs, which provide the flexibility to adjust trial characteristics on the basis of data reviewed at interim stages. Statisticians and clinical investigators have proposed or […]
Clinical Trials
Sunday, December 16th, 2012
Wiley: 12/13/12 Objective: Very low cerebral blood volume (VLCBV), diffusion and hypoperfusion lesion volumes have been proposed as predictors of hemorrhagic transformation following stroke thrombolysis. We aimed to compare these parameters, validate VLCBV in an independent cohort using DEFUSE study data and investigate the interaction of VLCBV with regional reperfusion. Methods: The EPITHET and DEFUSE studies […]
Clinical Trials
Sunday, December 16th, 2012
AHA: December 11, 2012 Background and Purpose—History of stroke and transient ischemic attack (TIA) are documented risk factors for subsequent stroke and all-cause mortality. Recent reports suggest increased risk among those reporting stroke symptoms absent stroke or TIA. However, the relative magnitude of increased stroke risk has not been described across the symptomatic spectrum: (1) […]
