Clinical Trials
Saturday, December 1st, 2012
AHA: 11/20/12 Background and Purpose—Different modes of administration are used to collect stroke outcomes, even within the same study, potentially leading to different results. We investigated the effect of administration mode (postal questionnaire; face-to-face interview) on self-reports of activities of daily living and mood. Methods—The study was nested within a poststroke motivational interviewing trial. Activities of […]
Clinical Trials
Saturday, December 1st, 2012
AHA: 10/2/12 Background and Purpose—Apixaban reduces stroke with comparable bleeding risks when compared with aspirin in patients with atrial fibrillation who are unsuitable for vitamin Kantagonist therapy. This analysis explores patterns of bleeding and defines bleeding risks based on stroke risk with apixaban and aspirin. Methods—The Apixaban versus Acetylsalicylic Acid to Prevent Stroke in Atrial Fibrillation Patients […]
Clinical Trials
Saturday, December 1st, 2012
AHA: 10/2/12 Background and Purpose—Dysphagia screening (DS) before oral intake in patients with acute stroke is a hospital-level performance measure. We report outcomes of an initiative to improve compliance to this quality measure. Methods—The design was a pre- versus postintervention comparison study. The Intervention was an electronic medical record-based clinical DS system embedded within stroke admission […]
Clinical Trials
Thursday, November 22nd, 2012
AHA: 11/16/12 Background—Stroke occurs more commonly after carotid artery stenting than carotid endarterectomy. Details regarding stroke type, severity, and characteristics have not been previously reported. We describe the strokes occurring in the Carotid Revascularization Endarterectomy versus Stenting Trial (CREST). Methods and Results—CREST is a randomized, open-allocation, controlled trial with blinded endpoint adjudication. Stroke was a […]
Clinical Trials
Thursday, November 22nd, 2012
Trials Journal: 11/16/12 Non-inferiority and equivalence trials require tailored methodology and therefore adequate conduct and reporting is an ambitious task. The aim of our review was to assess whether the criteria recommended by the CONSORT extension were followed. Methods: We searched the Medline database and the Cochrane Central Register for reports of randomised non-inferiority and equivalence trials […]
Clinical Trials
Thursday, November 22nd, 2012
Plosone: 11/15/12 Authors of randomized trial reports seem to hold a variety of views regarding the relationship between missing outcome data (MOD) and intention to treat (ITT). The objectives of this study were to systematically investigate how authors of methodology articles define ITT in the presence of MOD, how they recommend handling MOD under ITT, and […]
Clinical Trials
Thursday, November 22nd, 2012
Plosone: 11/14/12 Since September 2005, the International Committee of Medical Journal Editors (ICMJE) has required that randomised controlled trials (RCTs) are prospectively registered in a publicly accessible database. After registration, a trial registration number (TRN) is assigned to each RCT, which should make it easier to identify future publications and cross-check published results with associated registry […]
Clinical Trials
Thursday, November 22nd, 2012
AHA: 11/13/12 Background and Purpose—To assess whether the combined analysis of all phase III trials of nonvitamin-K-antagonist (non-VKA) oral anticoagulants in patients with atrial fibrillation and previous stroke or transient ischemic attack shows a significant difference in efficacy or safety compared with warfarin. Methods—We searched PubMed until May 31, 2012, for randomized clinical trials using the […]
Clinical Trials
Tuesday, November 20th, 2012
American Heart Association: November 13, 2012 Background and Purpose—The modified Rankin Scale (mRS) is the recommended functional outcome assessment in stroke trials. Utility of mRS may be limited by interobserver variability. prestroke function, described using mRS, is often used as trial entry criterion. We assessed the reliability and validity of prestroke mRS in acute stroke. Methods—We […]
Clinical Trials
Tuesday, November 20th, 2012
American Heart Association: November 13, 2012 Background—Blacks have disproportionately high rates of cardiovascular disease. Psychosocial stress may contribute to this disparity. Previous trials on stress reduction with the Transcendental Meditation (TM) program have reported improvements in cardiovascular disease risk factors, surrogate end points, and mortality in blacks and other populations. Methods and Results—This was a randomized, […]
