Clinical Trials
Friday, October 5th, 2012
Content.onlinejacc.org: October 2012 A Randomized Controlled Study The purpose of the present study was to test the potential of colchicine, an agent with potent anti-inflammatory action, to reduce atrial fibrillation (AF) recurrence after pulmonary vein isolation in patients with paroxysmal AF. Background Proinflammatory processes induced by AF ablation therapy have been implicated in postablation arrhythmia recurrence. Methods Patients […]
Clinical Trials
Friday, October 5th, 2012
Ctj.sagepub.com: October 1, 2012 Recent research has proposed a new method for defining a favorable outcome in traumatic brain injury and stroke research. Purpose This new method is called the sliding dichotomy, and it is suggested as a potential solution to the problem of underpowered clinical trials. Methods We present a brief simulation study and graphical comparison of […]
Clinical Trials
Friday, October 5th, 2012
Circ.ahajournals.org: October 1, 2012 The outcome of atrial fibrillation (AF) patients on warfarin partially depends on maintaining adequate time in therapeutic INR range (TTR). Large differences in TTR have been reported between centers and countries. The association between warfarin dosing practice, TTR, and clinical outcomes was evaluated in RE-LY trial patients receiving warfarin. Methods and Results—RE-LY […]
Clinical Trials
Thursday, September 27th, 2012
Onlinelibrary.wiley.com: 9/27/12 Transcranial laser therapy is undergoing clinical trials in patients with acute ischemic stroke. The NeuroThera® Efficacy and Safety Trial-1 was strongly positive for 90-day functional benefit with transcranial laser therapy, and post hoc analyses of the subsequent NeuroThera® Efficacy and Safety Trial-2 trial suggested a meaningful beneficial effect in patients with moderate to moderately severe […]
Clinical Trials
Thursday, September 27th, 2012
Circ.ahajournals.org: 9/26/12 The BARI 2D trial assigned patients with type 2 diabetes to prompt coronary revascularization (REV) plus intensive medical therapy versus intensive medical therapy (MED) alone and reported no significant difference in mortality. Among patients selected for CABG, REV was associated with a significant reduction in death/MI/stroke compared with MED. We hypothesized that clinical […]
Clinical Trials
Thursday, September 27th, 2012
Nejm.org: 8/30/12 Lacunar infarcts are a frequent type of stroke caused mainly by cerebral small-vessel disease. The effectiveness of antiplatelet therapy for secondary prevention has not been defined. We conducted a double-blind, multicenter trial involving 3020 patients with recent symptomatic lacunar infarcts identified by magnetic resonance imaging. Patients were randomly assigned to receive 75 mg […]
Clinical Trials
Thursday, September 27th, 2012
Stroke.ahajournals.org: 6/26/12 We report the primary outcome of the Cerecyte Coil Trial, a randomized trial to determine whether polymer-loaded Cerecyte coils compared with Micrus bare platinum coils improved the proportion of patients with angiographic occlusion of the aneurysm at 6 months when assessed by a core laboratory. The secondary objectives were to compare the clinical […]
Clinical Trials
Friday, September 21st, 2012
American Heart Association: September 18, 2012 There has been a nonstandard surgical procedure and extensive international controversy in minimally invasive surgery (MIS) for the management of spontaneous supratentorial intracerebral hemorrhage. This meta-analysis assessed the effectiveness of MIS as compared with other treatment options, including conservative medical treatment and conventional craniotomy, in patients with supratentorial intracerebral hemorrhage. […]
Clinical Trials
Friday, September 21st, 2012
Annals.org: September 18, 2012 Patients: 2298 adults ≥ 18 years of age (mean age 73 y, 50% women) who had acute ischemic stroke referable to the middle cerebral artery territory with compatible neuroimaging; symptom onset within 24 hours; score ≥ 8 on the National Institutes of Health Stroke Scale (NIHSS), of which ≥ 2 points were from sections 5 and […]
Clinical Trials
Friday, September 21st, 2012
American Heart Association: September 13, 2012 The American Stroke Association guidelines emphasized the need for further high-quality studies that assess agreement by radiologists and nonradiologists engaged in emergency telestroke assessments and decision-making. Therefore, the objective of this study was to determine the level of agreement of baseline brain CT scan interpretations of patients with acute stroke […]
