New Oral Anticoagulants for Atrial Fibrillation: A Review of Clinical Trials

Science Direct: Kate M. O’Dell, PharmD, BCPS,  March 12, 2012. Background Warfarin had been the only oral anticoagulant for stroke prevention in patients with atrial fibrillation (AF) for decades. Direct thrombin inhibitors and factor Xa inhibitors are new anticoagulants recently approved for prevention of stroke or systemic embolism in patients with AF. Objective The aim of […]

Closure or Medical Therapy for Cryptogenic Stroke with Patent Foramen Ovale

Nejm.org: Anthony J. Furlan, M.D., Mark Reisman, M.D., Joseph Massaro, Ph.D., Laura Mauri, M.D., Harold Adams, M.D., Gregory W. Albers, M.D., Robert Felberg, M.D., Howard Herrmann, M.D., Saibal Kar, M.D., Michael Landzberg, M.D., Albert Raizner, M.D., and Lawrence Wechsler, M.D. for the CLOSURE I Investigators N Engl J Med 2012; 366:991-999 – March 15, 2012. […]

Does Consideration and Assessment of Effects on Health Equity Affect the Conclusions of Systematic Reviews? A Methodology Study

Plosone: Vivian Welch1,2*, Mark Petticrew3, Erin Ueffing4, Maria Benkhalti Jandu2, Kevin Brand5, Bharbhoor Dhaliwal2, Elizabeth Kristjansson6, Janet Smylie7,8, George Anthony Wells9,10, Peter Tugwell1,2,11 – March 13, 2012.   Abstract Top Introduction Tackling health inequities both within and between countries remains high on the agenda of international organizations including the World Health Organization and local, regional and national […]

Could the immune system help recovery from stroke?

physorg.com: March 13th, 2012. Stroke and other diseases and injuries to the brain are often followed by inflammation, caused by a reaction of the body’s immune system. This reaction has been seen as something that must be combated, but perhaps the immune system could in fact help with recovery following a stroke. A major new EU […]

The Role of Statin Therapy in the Prevention of Atrial Fibrillation: A Meta-Analysis of Randomized Controlled Trials

Onlinelibrary.wiley.com: Wen-tong Fang MD1, Hong-jian LI MD2, Haibo Zhang MD1, Su Jiang BD1 – March 9, 2012. Summary Aims:  To examine whether statins can reduce the risk of atrial fibrillation (AF). Background:  The use of statins had been suggested to protect against AF in some clinical observational and experimental studies but has remained inadequately explored. Methods:  Meta analysis of […]

Mild hypothermia of 34degreesC reduces side effects of rt-PA treatment after thromboembolic stroke in rats

Etsmjournal.com: Bernd Kallmunzer, Stefan Schwab and Rainer Kollmar – March 7, 2012. Abstract (provisional) Background Hypothermia is neuroprotective in experimental stroke and may extend the so far limited therapeutic time window for thrombolysis. Therefore, hypothermia of 34degreesC and its effects on delayed thrombolysis including reperfusion-associated injury were investigated in a model of thromboembolic stroke (TE). Methods Male Wistar rats (n=48) […]

Physicians study human stem cell use as possible treatment for ischemic stroke

News-Medical: Published on March 7, 2012 at 4:28 AM. Physicians at the Methodist Neurological Institute are studying the use of human stem cells as a possible treatment for acute ischemic stroke, a leading cause of death and disability. Each year, stroke affects more than 15 million people around the world. Patients whose ischemic strokes occur within one to two days of […]

New approach to stroke therapy

Toxic gas protects brain function in animal model Eurekalert: Dr. Kathrin Bilgeri- March 5, 2012. LMU researchers developed a new strategy for the treatment of stroke, which could help to improve blood flow to ischemic brain. Strokes are due to a localized reduction in the blood supply to the brain, mainly due to the blockage of a […]

International voice in human subjects protections named NIH Clinical Center bioethics chief

NIH.gov: Maggie McGuire, NIH Clinical Center – Friday, March 2, 2012. Christine Grady, Ph.D., was recently named chief of the Department of Bioethics of the National Institutes of Health (NIH) Clinical Center. Grady has served as deputy director of the department since 1996 and served as acting chief since September 2011. Her research focuses on clinical research […]

ISPE Issues Guidance for Clinical Trials Comparator Management

Guide explains issues related to comparator sourcing, outlines strategies for saving time and money in regards to comparator management. PRweb: Tampa, Florida USA (PRWEB) March 01, 2012. ISPE announced today that it has issued important industry guidance to advise clinical trials on comparator management activities. The ISPE Good Practice Guide: Comparator Management is the pharmaceutical industry’s first-ever […]

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