Clinical Trials
Wednesday, April 23rd, 2014
STROKEAHA: April 3, 2014 Background and Purpose—Severe atherosclerosis in the aortic arch is associated with a high risk of recurrent vascular events, but the optimal antithrombotic strategy is unclear. Methods—This prospective randomized controlled, open-labeled trial, with blinded end point evaluation (PROBE design) tested superiority of aspirin 75 to 150 mg/d plus clopidogrel 75 mg/d (A+C) over […]
Clinical Trials
Wednesday, April 23rd, 2014
STROKEAHA: April 3, 2014, Background and Purpose—Previous cell-based and animal studies showed mixed tocotrienols are neuroprotective, but the effect is yet to be proven in humans. Thus, the present study aimed to evaluate the protective activity of mixed tocotrienols in humans with white matter lesions (WMLs). WMLs are regarded as manifestations of cerebral small vessel disease, […]
Clinical Trials
Wednesday, April 23rd, 2014
STROKEAHA: April 1, 2014 Background and Purpose—Atrial fibrillation is associated with decline of cognitive function. Observational evidence suggests that anticoagulation might protect against this decline. We report the first randomized controlled trial evidence on the effect of anticoagulation on cognitive function in elderly patients with atrial fibrillation. Methods—A total of 973 patients aged ≥75 years with […]
Clinical Trials
Wednesday, April 23rd, 2014
STROKEAHA: March 27, 2014 Background and Purpose—Blood pressure (BP) reduction lowers vascular risk after stroke; however, little is known about the relationship between consistency of BP control and risk of subsequent vascular events. Methods—In this post hoc analysis of the Vitamin Intervention for Stroke Prevention trial (n=3680), individuals with recent (<120 days) stroke, followed up for […]
Clinical Trials
Wednesday, April 2nd, 2014
BMJ: 3/20/14 Abstract Introduction Concomitant surgical ablation is a treatment modality for patients with atrial fibrillation (AF) undergoing cardiac surgery, however, its efficacy and clinical outcomes are not well established. The present study is the first cumulative meta-analysis of randomised controlled trials (RCT) on clinical outcomes of surgical ablation versus no ablative treatment in all patients with […]
Clinical Trials
Wednesday, April 2nd, 2014
Wiley: MAR 12, 2014 Background In the interest of prioritizing resources and providing future direction for researchers, a complete overview of the landscape of stroke rehabilitation literature was conducted. Aim We aimed to examine the evolution of stroke rehabilitation randomized controlled trials, with respect to number, sample size, and methodological quality between 1970 and September 2012. […]
Clinical Trials
Wednesday, April 2nd, 2014
STROKEAHA: March 6, 2014 Background and Purpose—Intravenous recombinant tissue-type plasminogen activator (rtPA), despite a risk of early symptomatic intracranial hemorrhage (sICH), is of net clinical benefit to acute stroke patients. We tested if predictive models could identify patients least likely to be harmed by sICH or those who gained no net benefit. Methods—We used the Third […]
Clinical Trials
Wednesday, April 2nd, 2014
JACC in a Flash: 3/1/14 In patients with atrial fibrillation (AF), anticoagulation strategies must be carefully selected—taking into consideration the risk of bleeding and thromboembolic events and the interaction with potential treatments to correct cardiac arrhythmias. Three novel oral anticoagulant (NOAC) drugs have been approved for stroke prevention in these patients over the last few years, […]
Clinical Trials
Wednesday, April 2nd, 2014
STROKEAHA: January 23, 2014 Medical students in the 1940s observed that stroke victims were regarded as in a hopeless situation. Severely disabled patients with stroke and those in coma from intracerebral clots were confined to Observation Units. What was learned in my early days allowed us to replace this Medical Bedlam with Stroke Prevention and Treatment […]
Clinical Trials
Sunday, March 2nd, 2014
STROKEAHA: February 25, 2014 Background and Purpose—Our aim was to determine the relationships between angiographic collaterals and diffusion/perfusion findings, subsequent infarct growth, and clinical outcome in patients undergoing endovascular therapy for ischemic stroke. Methods—Sixty patients with a thrombolysis in cerebral infarction (TICI) score of 0 or 1 and internal carotid artery/M1 occlusion at baseline were evaluated. […]
