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Thursday, January 9th, 2014
STROKEAHA: December 10, 2013 Coffee, tea, and cocoa are important dietary sources of polyphenols and have received much attention during the past years because of their potential beneficial effects on cardiovascular health. The polyphenols in these beverages and cocoa may reduce the risk of stroke through multiple mechanisms, including antihypertensive, hypocholesterolemic, antioxidant, and anti-inflammatory effects as […]
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Saturday, December 14th, 2013
STROKEAHA: December 12, 2013 Background and Purpose—Several risk scores have been developed to predict the stroke risk after transient ischemic attack (TIA). However, the validation of these scores in different cohorts is still limited. The objective of this study was to elucidate whether these scores were able to predict short-term and long-term risks of stroke in […]
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Saturday, December 14th, 2013
CIRCOUTCOMES: December 10, 2013 Background—The prevalence of severe obesity is rising in the United States. Although mild to moderately elevated body mass index (BMI) is associated with reduced mortality after acute ischemic stroke, less is known about severe obesity. Methods and Results—Patients with acute ischemic stroke (n=1791) ≥45 years were identified from the biethnic population–based Brain […]
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Saturday, December 14th, 2013
STROKEAHA: December 12, 2013 Background and Purpose—Because robotic devices record the kinematics and kinetics of human movements with high resolution, we hypothesized that robotic measures collected longitudinally in patients after stroke would bear a significant relationship to standard clinical outcome measures and, therefore, might provide superior biomarkers. Methods—In patients with moderate-to-severe acute ischemic stroke, we used […]
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Saturday, December 14th, 2013
STROKEAHA: December 12, 2013 Background and Purpose—The Interventional Management of Stroke (IMS)-III trial randomized patients with acute ischemic stroke to intravenous tissue-type plasminogen activator (tPA) plus endovascular therapy versus intravenous tPA therapy alone within 3 hours from symptom onset. A predefined secondary hypothesis was that subjects with significant early ischemic change on the baseline scan would […]
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Saturday, December 14th, 2013
Nature Reviews Neurology: 10 December 2013 Subarachnoid haemorrhage (SAH) causes early brain injury (EBI) that is mediated by effects of transient cerebral ischaemia during bleeding plus effects of the subarachnoid blood. Secondary effects of SAH include increased intracranial pressure, destruction of brain tissue by intracerebral haemorrhage, brain shift, and herniation, all of which contribute to pathology. […]
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Saturday, December 14th, 2013
STROKEAHA: December 5, 2013 Background and Purpose—Whether transient global amnesia (TGA) represents an arterial insult that heralds ischemic stroke remains unclear. Therefore, we examined stroke risk after TGA in a population-based cohort. Methods—After performing chart review at our institution to validate the International Classification of Diseases, 9th Edition, Clinical Modification diagnosis code for TGA, we used […]
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Saturday, December 14th, 2013
STROKEAHA: December 3, 2013 Background and Purpose—Arterial spin labeling (ASL) is a perfusion magnetic resonance imaging (MRI) technique that does not require contrast administration and thus may be more practical in hyperacute stroke than susceptibility-weighted bolus-tracking perfusion-weighted imaging (PWI). However, a threshold for ASL measurement of the ischemic penumbra needs to be determined. Read More
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Saturday, December 14th, 2013
STROKEAHA: November 26, 2013 Expanding the Concept of Poststroke Disability Background and Purpose—Limitations in essential daily activities are common among older adults after stroke, but little is known about restrictions in their ability to participate in valued social activities. We sought to broaden our understanding of disability after stroke by characterizing poststroke participation restrictions and investigating […]
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Saturday, December 14th, 2013
The Lancet, Early Online Publication, 22 November 2013 Body-mass index (BMI) and diabetes have increased worldwide, whereas global average blood pressure and cholesterol have decreased or remained unchanged in the past three decades. We quantified how much of the effects of BMI on coronary heart disease and stroke are mediated through blood pressure, cholesterol, and […]
