Poststroke anxiety is prevalent at the population level, especially among socially deprived and younger age community stroke survivors

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Wiley: 11/10/13 Background Most studies of poststroke anxiety prevalence are hospital based, so knowledge of anxiety in community stroke survivors is limited. Few studies address the association between poststroke anxiety and patient age. No study has explored the relationship between poststroke anxiety prevalence and social deprivation. Aims This study aims to describe population level prevalence […]

2013 Thomas Willis Award Lecture

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STROKEAHA: November 7, 2013 The pathophysiology of stroke is complex. Adaptive and maladaptive signalling occurs between multiple cell types in the brain. There is crosstalk between central and systemic responses. And there are overlapping pathways during initial injury and subsequent repair. These numerous feed-forward and feed-back interactions have made it difficult to translate experimental discoveries into […]

Adiponectin and Risk of Stroke: Prospective Study and Meta-analysis

STROKEAHA: November 7, 2013 Background and Purpose—The favorable cardiovascular effects attributed to adiponectin may lower risk of stroke. We investigated this in a prospective study and meta-analysis. Methods—A case–cohort study nested within the Potsdam cohort of the European Prospective Investigation into Cancer was performed, with 170 incident cases of ischemic stroke and a randomly selected subcohort […]

Association of Testosterone Therapy With Mortality, Myocardial Infarction, and Stroke in Men With Low Testosterone Levels

JAMA: 11/6/13 Importance  Rates of testosterone therapy are increasing and the effects of testosterone therapy on cardiovascular outcomes and mortality are unknown. A recent randomized clinical trial of testosterone therapy in men with a high prevalence of cardiovascular diseases was stopped prematurely due to adverse cardiovascular events raising concerns about testosterone therapy safety. Objectives  To assess the […]

Aphasia and dysarthria in acute stroke: recovery and functional outcome

Wiley: 11/6/13 Aphasia and dysarthria have major implications for activities of daily living and social participation following stroke. Few studies describe recovery in the acute stroke setting. We described the evolution of aphasia and dysarthria by three-months poststroke. Methods We conducted a retrospective analysis of pooled clinical trial data from the Virtual International Stroke Trials Archive. […]

Interrelationship Among Common Medical Complications After Acute Stroke

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STROKEAHA: October 31, 2013 Background and Purpose—Medical complications are common among patients with stroke. However, little is known about the potential interrelationship among them. In the present study, we aimed to investigate the association between common in-hospital medical complications after acute ischemic stroke (AIS) and spontaneous intracerebral hemorrhage (ICH). Methods—We analyzed patients enrolled in the China […]

Cerebral Microbleeds as a Predictor of 1-Year Outcome of Poststroke Depression

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STROKEAHA: October 31, 2013 Background and Purpose—Cerebral microbleeds (CMBs) are common in stroke survivors and community-dwelling elderly. The clinical significance of CMBs in the outcome of poststroke depression (PSD) is unknown. This study examined the association between the 1-year outcome of PSD and CMBs. Methods—The study population comprised 774 Chinese patients with acute ischemic stroke who […]

Preventable Readmissions Within 30 Days of Ischemic Stroke Among Medicare Beneficiaries

STROKEAHA: October 30, 2013 Background and Purpose—The Centers for Medicare and Medicaid Services proposes to use 30-day hospital readmissions after ischemic stroke as part of the Hospital Inpatient Quality Reporting Program for payment determination beginning in 2016. The proportion of poststroke readmissions that is potentially preventable is unknown. Methods—Thirty-day readmissions for all Medicare fee-for-service beneficiaries aged […]

A systematic review and meta-analysis of acute stroke unit care: What’s beyond the statistical significance?

BMC:  10/28/13 Background The benefits of stroke unit care in terms of reducing death, dependency and institutional care were demonstrated in a 2009 Cochrane review carried out by the Stroke Unit Trialists’ Collaboration. Methods As requested by the Belgian health authorities, a systematic review and meta-analysis of the effect of acute stroke units was performed. […]

Depression: Cognition relations after stroke

Wiley: OCT 27, 2013 Background Poststroke depression and cognitive dysfunction are common and are independent predictors of poor recovery. Aims We assessed whether and how depression and cognition were correlated in the subacute period after stroke. Method We prospectively recruited 207 nondemented patients (Mini Mental State Examination ≥ 23) presenting with a first-ever ischemic stroke (127 males), […]

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