Clinical Decision Rules to Rule Out Subarachnoid Hemorrhage for Acute Headache

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JAMA: 9/25/13 Importance  Three clinical decision rules were previously derived to identify patients with headache requiring investigations to rule out subarachnoid hemorrhage. Objective  To assess the accuracy, reliability, acceptability, and potential refinement (ie, to improve sensitivity or specificity) of these rules in a new cohort of patients with headache. Design, Setting, and Patients  Multicenter cohort study conducted at 10 […]

Burden and Outcome of Prevalent Ischemic Brain Disease in a National Acute Stroke Registry

STROKEAHA: September 24, 2013 Background and Purpose—Previous overt stroke and subclinical stroke are frequent in patients with stroke; yet, their clinical significance and effects on stroke outcome are not clear. We studied the burden and outcome after acute ischemic stroke by prevalent ischemic brain disease in a national registry of hospitalized patients with acute stroke. Methods—Patients […]

Toward Solutions for Minimizing Disparities in Stroke

STROKEAHA:  September 10, 2013 The higher burden that many diseases pose on racial and ethnic minorities in the United States represents one of the most significant public health problems facing modern society. Stroke is no exception, with dramatic disparities in incidence and outcome among racial and ethnic minorities, rural, and disadvantaged socioeconomic groups. National Institute […]

Toward a Stroke-Free Childhood in Sickle Cell Disease

AHA Stroke: September 5, 2013   Stroke in childhood is not common outside of congenital heart disease and a few other conditions including sickle cell disease (SCD). The background rates reported have been between 2.3 and 2.7 per 100 000 per year.1–3 Adults, on the contrary, have a background rate of ≈800 per 100 000.4 There are some […]

Does Socioeconomic Status or Acculturation Modify the Association Between Ethnicity and Hypertension Treatment Before Stroke?

STROKEAHA: September 17, 2013 Background and Purpose—Socioeconomic status and acculturation may modify the association between ethnicity and hypertension treatment before stroke. We assessed prestroke treatment of hypertension by ethnicity, education (proxy for socioeconomic status), and English proficiency (EP; proxy for acculturation) in a population-based stroke surveillance project. Methods—Among 763 patients with first-ever stroke aged ≥45 […]

Temporal Trends in Patient Characteristics and Treatment With Intravenous Thrombolysis Among Acute Ischemic Stroke Patients at Get With the Guidelines–Stroke Hospitals

AHA: Cardiovascular Quality and Outcomes 9/1/13   Background—Substantial efforts over the past decade have increased rates of intravenous tissue plasminogen activator (tPA) use in the United States. We sought to determine changes in patient characteristics and rates of tPA use over time among hospitalized acute ischemic stroke (AIS) patients. Methods and Results—We analyzed all AIS patients […]

Perceived neighborhood social cohesion and stroke

ScienceDirect: 8/23/13 Research in the last three decades has shown that negative neighborhood factors such as neighborhood violence, noise, traffic, litter, low neighborhood socioeconomic status, and poor air quality increase the risk of poor health. Fewer studies have examined the potential protective effect that neighborhood factors can have on health, particularly stroke. We examined whether higher […]

Mediterranean diet, stroke, cognitive impairment, and depression: A meta-analysis

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Wiley: 9/16/13 This meta-analysis aims to quantitatively synthesize all studies that examine the association between adherence to a Mediterranean diet and risk of stroke, depression, cognitive impairment, and Parkinson disease. Methods Potentially eligible publications were those providing effect estimates of relative risk (RR) for the association between Mediterranean diet and the aforementioned outcomes. Studies were sought […]

NA in blood is altered prior to hemorrhagic transformation in ischemic stroke

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Wiley: 9/10/13 Hemorrhagic transformation (HT) is a major complication of ischemic stroke that worsens outcomes and increases mortality. Disruption of the blood–brain barrier is a central feature of HT pathogenesis, and leukocytes may contribute to this process. We sought to determine whether ischemic strokes that develop HT have differences in RNA expression in blood within […]

Predictors of in-hospital death and symptomatic intracranial hemorrhage in patients with acute ischemic stroke treated with thrombolytic therapy: Paul Coverdell Acute Stroke Registry 2008–2012

Wiley: 9/12/13 Limited studies exist on the outcome of thrombolytic therapy of acute ischemic stroke patients outside of clinical trials. Aim To assess the possible risk factors associated with in-hospital death and symptomatic intracerebral hemorrhage among patients who received intravenous tissue plasminogen activator. Methods A total of 7193 patients with a clinical diagnosis of acute ischemic […]

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