Genome-Wide Analysis of Blood Pressure Variability and Ischemic Stroke

STROKEAHA: August 8, 2013 Background and Purpose—Visit-to-visit variability in blood pressure (vBP) is associated with ischemic stroke. We sought to determine whether such variability has genetic causes and whether genetic variants associated with BP variability are also associated with ischemic stroke. Methods—A Genome Wide Association Study (GWAS) for loci influencing BP variability was undertaken in 3802 […]

Risk of incident stroke in patients with Alzheimer disease or vascular dementia

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Neurology: 7/31/13 Objective: To explore the risk of ischemic stroke, hemorrhagic stroke, or TIA in patients with Alzheimer disease (AD) or vascular dementia (VD). Methods: We conducted a follow-up study with a nested case-control analysis using the UK-based General Practice Research Database. We included patients aged 65 years and older with an incident diagnosis of AD or VD […]

Triple dissociation of attention networks in stroke according to lesion location

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Neurology: 7/31/13 Objective: To determine whether behavioral dissociations and interactions occur between the attentional functions—alerting, orienting, and conflict resolution—depending upon stroke location and to determine the approximate proportion of patients who can be classified into 1 of these 3 anatomical networks. Methods: We recruited 110 anatomically unselected acute stroke patients and 62 age-matched controls. Subjects underwent the attention […]

The Age-Specific Quantitative Effects of Metabolic Risk Factors on Cardiovascular Diseases and Diabetes: A Pooled Analysis

Plosone: 7/30/13 The effects of systolic blood pressure (SBP), serum total cholesterol (TC), fasting plasma glucose (FPG), and body mass index (BMI) on the risk of cardiovascular diseases (CVD) have been established in epidemiological studies, but consistent estimates of effect sizes by age and sex are not available. Methods We reviewed large cohort pooling projects, evaluating […]

Predictors of Stroke in Patients With Impaired Glucose Tolerance

STROKEAHA:  July 30, 2013 Results From the Nateglinide and Valsartan in Impaired Glucose Tolerance Outcomes Research Trial Background and Purpose—Risk factors for stroke are well-established in general populations but sparsely studied in individuals with impaired glucose tolerance. Methods—We identified predictors of stroke among participants with impaired glucose tolerance in the Nateglinide and Valsartan in Impaired […]

Sexual Counseling for Individuals With Cardiovascular Disease and Their Partners

American Heart Association:  July 29, 2013 After a cardiovascular event, patients and their families often cope with numerous changes in their lives, including dealing with consequences of the disease or its treatment on their daily lives and functioning. Coping poorly with both physical and psychological challenges may lead to impaired quality of life. Sexuality is one aspect of quality of […]

The Association Between Stroke, Depression, and 5-Year Mortality Among Very Old People

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STROKEAHA:  July 23, 2013   Background and Purpose—Depression after stroke has been associated with increased mortality, but little is known about this association among very old people. Methods—A population-based study among people ≥85 years of age was conducted in northern Sweden and Finland, comprising cross-sectional assessments and subsequent survival data. The 452 individuals who had […]

Persistent ischemic stroke disparities despite declining incidence in Mexican Americans

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Wiley:  7/19/13 OBJECTIVE: To determine trends in ischemic stroke incidence among Mexican Americans and non Hispanic Whites. METHODS: We performed population-based stroke surveillance from January 1, 2000 – December 31, 2010 in Corpus Christi, Texas. Ischemic stroke cases 45 years and over were ascertained from potential sources and charts abstracted. Neurologists validated cases based on […]

Physical Activity Frequency and Risk of Incident Stroke in a National US Study of Blacks and Whites

STROKEAHA: July 18, 2013 Background and Purpose—Regular physical activity (PA) is an important recommendation for stroke prevention. We compared the associations of self-reported PA with incident stroke in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study. Methods—REGARDS recruited 30 239 US blacks (42%) and whites, aged ≥45 years with follow-up every 6 months […]

Profiles of the National Institutes of Health Stroke Scale Items as a Predictor of Patient Outcome

STROKEAHA: May 23, 2013   Background and Purpose—Initial National Institutes of Health Stroke Scale (NIHSS) score is highly predictive of outcome after ischemic stroke. We examined whether grouping strokes by presence of individual NIHSS symptoms could provide prognostic information additional or alternative to the NIHSS total score. Methods—Ischemic strokes from the Greater Cincinnati Northern Kentucky Stroke […]

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