Genetics of Stroke: The Impact and Limitations of Evolving Technology

lady

Stroke June 1, 2013 There have been advances in understanding the molecular underpinnings of risk and response to stroke hailing from genetic research. Traditional linkage studies were limited to identifying genetic mutations, representing small fractions of human disease burden. Yet with large-scale genotyping, RNA expression studies and microRNA analyses, modern genetic research has opened the […]

Stroke Progress Review Group: Looking Back and Going Forward

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Stroke june 1, 2013 This session of the Princeton Conference highlighted the goals and progress of the Stroke Progress Review Group. The Stroke Progress Review Group was formed in 2001 to focus research efforts in (1) stroke treatment, (2) stroke prevention, and (3) stroke recovery. In the area of preclinical stroke research, the need for […]

The Current State and Future of Stroke

Stroke:  June 1, 2013 The presentations and accompanying papers during this session of the Princeton Conference highlight that although we have seen favorable trends in stroke burden in the United States (eg, declining incidence and mortality rates), stroke continues to represent a major challenge to public health. As described by Kim et al,1 stroke will take […]

Cholesterol Levels and Risk of Hemorrhagic Stroke

STROKEAHA: May 23, 2013 Background and Purpose—Cholesterol levels are inconsistently associated with the risk of hemorrhagic stroke. The purpose of this study is to assess their relationships using a meta-analytic approach. Methods—We searched PubMed and Embase for pertinent articles published in English. Only prospective studies that reported effect estimates with 95% confidential intervals (CIs) of hemorrhagic […]

Depression and Risk of Stroke in Midaged Women

Stroke: May 16, 2013 Background and Purpose—Depression is known to increase stroke risk. Although limited, there is some evidence for age differences, with a suggestion for a stronger association in younger groups. We investigated the effect of depression on stroke incidence in a large cohort of midaged women. Methods—We included 10 547 women without a history […]

AHA/ASA Policy Statement Forecasting the Future of Stroke in the United States

mombaby

StrokeAHA: May 22, 2013 Background and Purpose—Stroke is a leading cause of disability, cognitive impairment, and death in the United States and accounts for 1.7% of national health expenditures. Because the population is aging and the risk of stroke more than doubles for each successive decade after the age of 55 years, these costs are anticipated […]

Cooperative Strategies to Develop Effective Stroke and Heart Attack Awareness Messages in Rural American Indian Communities, 2009–2010

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CDC: May 16, 2013 Introduction National initiatives to improve the recognition of heart attack and stroke warning signs have encouraged symptomatic people to seek early treatment, but few have shown significant effects in rural American Indian (AI) communities. Methods During 2009 and 2010, the Montana Cardiovascular Health Program, in collaboration with 2 tribal health departments, […]

Racial and Ethnic Differences in Outcomes in Older Patients With Acute Ischemic Stroke

CIRCOUTCOMES: May 16, 2013 Background—Little is known as to whether long-term outcomes of acute ischemic stroke (AIS) vary by race/ethnicity. Using the American Heart Association Get With The Guidelines–Stroke registry linked with Medicare claims data set, we examined whether 30-day and 1-year outcomes differed by race/ethnicity among older patients with AIS. Methods and Results—We analyzed 200 […]

Baseline Cognitive Function, Recurrent Stroke, and Risk of Dementia in Patients With Stroke

STROKEAHA: May 16, 2013 Background and Purpose—To determine the interrelationships between baseline Mini-Mental State Examination (MMSE) score and risk of overall dementia, post-recurrent stroke dementia, and dementia without recurrent stroke among patients with a history of stroke. Methods—Prospective cohort study among participants enrolled in the Perindopril Protection Against Recurrent Stroke Study (PROGRESS) for whom baseline MMSE […]

Framingham Stroke Risk Score and Cognitive Impairment for Predicting First-Time Stroke in the Oldest Old

STROKEAHA May 16, 2013 Background and Purpose—Predictive value of the conventional risk factors for stroke attenuates with age. Cognitive impairment has been implicated as a potential predictor for stroke in older subjects. Our aim was to compare the Framingham stroke risk score with cognitive functioning for predicting first-time stroke in a cohort of the oldest old […]

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