Therapies
Thursday, September 5th, 2013
STROKEAHA: September 3, 2013 Background and Purpose—To determine the effect of intravenous tissue plasminogen activator (IV-tPA) on outcomes in patients with severe major anterior circulation ischemic stroke. Methods—Prospectively, 649 patients with acute stroke had admission National Institutes of Health stroke scale (NIHSS) scores, noncontrast computed tomography (CT), CT angiography (CTA), and 6-month outcome assessed using modified […]
Therapies
Thursday, September 5th, 2013
STROKEAHA: September 3, 2013 Background and Purpose—Patients with renal impairment (RI) have an increased risk of both thrombotic and hemorrhagic events. We aimed to clarify whether RI increases the risk of intracerebral hemorrhage (ICH) after intravenous thrombolysis with recombinant tissue plasminogen activator. Methods—Patients who received intravenous thrombolysis with recombinant tissue plasminogen activator within 4.5 hours of […]
Therapies
Thursday, September 5th, 2013
J NeuroIntervent Surg: 8/30/13 Parenchymal blood volume (PBV) mapping with flat panel detectors may provide real-time estimates of tissue perfusion during endovascular ischemic stroke procedures. We present two cases of acute middle cerebral artery (MCA) occlusion to demonstrate how PBV may: (1) be used in acute stroke; (2) influence intraprocedural decision-making; and (3) potentially serve as […]
Therapies
Friday, August 30th, 2013
AHA: 8/29/13 A Policy Statement From the American Heart Association/American Stroke Association In the United States and other parts of the world, various cities, states, and regions are developing multitiered systems for the care of patients with acute stroke. These systems often involve a range of healthcare components supported by various rules and regulations. The present policy statement will put […]
Therapies
Friday, August 30th, 2013
Nature Reviews Neurology: 8/27/13 The incidence of acute ischaemic stroke with mild neurological deficits (called mild ischaemic stroke [MIS]) is increasing, and studies show that a large percentage of untreated patients have poor long-term outcomes. Many physicians do not, however, routinely treat patients with MIS with intravenous recombinant tissue plasminogen activator (rtPA)—the only thrombolytic therapy currently […]
Therapies
Friday, August 30th, 2013
STROKEAHA: August 27, 2013 Background and Purpose—Prehospital redirection of stroke patients to a regional center is used as a strategy to maximize the provision of intravenous thrombolysis. We developed a model to quantify the benefit of redirection away from local services that were already providing thrombolysis. Methods—A microsimulation using hospital and ambulance data from consecutive emergency […]
Therapies
Friday, August 30th, 2013
Wiley: 8/26/13 Background There are limited data regarding the use of intravenous thrombolysis in patients who experienced acute ischemic symptoms during their hospitalization for prior transient ischemic attack. Aim We sought to prospectively evaluate the safety and efficacy of intravenous thrombolysis for the treatment of acute ischemic stroke occurring during hospitalization for transient ischemic attack in […]
Therapies
Friday, August 30th, 2013
STROKEAHA: 8/6/13 Intra-arterial therapy (IAT) for acute ischemic stroke (AIS) has dramatically evolved during the past decade to include aspiration and stent-retriever devices. Recent randomized controlled trials have demonstrated the superior revascularization efficacy of stent-retrievers compared with the first-generation Merci device.1,2 Additionally, the Diffusion and Perfusion Imaging Evaluation for Understanding Stroke Evolution (DEFUSE) 2, the Mechanical Retrieval […]
Therapies
Friday, August 23rd, 2013
STROKEAHA. August 22, 2013 Do All Patients Benefit Similarly? Background and Purpose—We previously reported increased benefit and reduced mortality after ultra-early stroke thrombolysis in a single center. We now explored in a large multicenter cohort whether extra benefit of treatment within 90 minutes from symptom onset is uniform across predefined stroke severity subgroups, as compared with […]
Therapies
Friday, August 23rd, 2013
BMC: August 19, 2013 Translating evidence into practice is an important final step in the process of evidence-based practice. Medical record audits can be used to examine how well practice compares with published evidence, and identify evidence-practice gaps. After providing audit feedback to professionals, local barriers to practice change can be identified and targetted with […]
