Concerns about medications mediate the association of posttraumatic stress disorder with adherence to medication in stroke survivors

Wiley: JAN 7, 2013 Objectives Post-traumatic stress disorder (PTSD) can be a consequence of acute medical events and has been associated with non-adherence to medications. We tested whether increased concerns about medications could explain the association between PTSD and non-adherence to medication in stroke survivors. Design We surveyed 535 participants aged 40 years or older who had […]

An Observational Study of Thrombolysis Outcomes in Wake-Up Ischemic Stroke Patients

STROKEAHA: January 3, 2013 Background and Purpose—Wake-up ischemic stroke (WUIS) patients are not eligible for thrombolysis; the a priori hypothesis was that thrombolysis of selected WUIS patients who meet clinical and imaging criteria for treatment is associated with better outcomes. Methods—The sample consisted of consecutive WUIS patients who fulfilled predefined criteria: (1) were last seen normal […]

Post Stroke Use of Selective Serotonin Reuptake Inhibitors and Clinical Outcome Among Patients With Ischemic Stroke

STROKEAHA: January 10, 2013 Background and Purpose—Selective serotonin reuptake inhibitors (SSRIs) are widely prescribed after stroke. We aimed to investigate whether potential antiplatelet or vasospastic effects have important clinical implications. Methods—Using data from Danish medical registries, we did a nationwide follow-up study among ischemic stroke patients between 2003 and 2009. We identified 5833 SSRI users, and […]

Selection for delayed intravenous alteplase treatment based on a prognostic score

Wiley: JAN 7, 2013 Background and Purpose Approved use of intravenous alteplase for ischemic stroke offers net benefit. Pooled randomized controlled trial analysis suggests additional patients could benefit but others be harmed with treatment initiated beyond 4·5 h after stroke onset. We proposed prognostic scoring methods to identify a strategy for patient selection. Methods We selected 500 […]

Statin Therapy and Outcome After Ischemic Stroke

STROKEAHA: January 3, 2013 Background—Although experimental data suggest that statin therapy may improve neurological outcome after acute cerebral ischemia, the results from clinical studies are conflicting. We performed a systematic review and meta-analysis investigating the relationship between statin therapy and outcome after ischemic stroke. Methods—The primary analysis investigated statin therapy at stroke onset (prestroke statin use) […]

Subarachnoid Hemorrhage in a Multimodal Approach Heavily Weighted Toward Mechanical Thrombectomy With Solitaire Stent in Acute Stroke

STROKEAHA: January 3, 2013 Background and Purpose—Subarachnoid hemorrhage (SAH) may appear on computerized tomography scans after mechanical thrombectomy for acute ischemic stroke. The incidence and prognosis of this observation remain unknown. We investigated the frequency and clinical consequences of SAH after treating acute ischemic stroke with multimodal approach heavily weighted toward mechanical thrombectomy with Solitaire stent. […]

From what we know to what we do: translating stroke rehabilitation research into practice

Wiley: DEC 24, 2012 Despite the recent advances in stroke rehabilitation research, the translation of research evidence into practice remains a challenge. The purpose of this article is to communicate practical experience and describe research methodologies used to promote change and implementation of stroke rehabilitation research in three international settings. In England, the development of an […]

Evidence-Based Community Stroke Rehabilitation

STROKEAHA: October 23, 2012 Survival after stroke initially can depend on the acute phase of specialist hospital care; however, the greatest impact on patient health and well-being is from the long-term consequences faced when stroke survivors leave the hospital. Optimal recovery requires the provision of coordinated specialist rehabilitation, not only in the early stages of returning […]

ACCF/AHA/HRS Practice Guideline

heartbeat

AHA: 12/19/12 It is important that the medical profession play a significant role in critically evaluating the use of diagnostic procedures and therapies as they are introduced and tested in the detection, management, or prevention of disease states. Rigorous and expert analysis of the available data documenting absolute and relative benefits and risks of those procedures and therapies can produce helpful guidelines […]

Clipping Versus Coiling for Ruptured Intracranial Aneurysms

AHA: December 13, 2012 Background and Purpose—Endovascular treatment has increasingly been used for aneurismal subarachnoid aneurismal hemorrhage. The aim of this analysis is to assess the current evidence regarding safety and efficiency of clipping compared with coiling. Methods—We conducted a meta-analysis of studies that compared clipping with coiling between January 1999 and July 2012. Comparison […]

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