Statins, Risk of Diabetes, and Implications on Outcomes in the General Population ONLINE FIRST

American College of Cardiology Foundation: August 9, 2012 This analysis aimed to evaluate the association of statin exposure and incident diabetes, and subsequent outcomes in the general population. Background  Cardiovascular events as consequences of atherosclerosis and diabetes are reduced by statins. However, statins are associated with excessive risk of diabetes occurrence according to clinical trial analyses. From […]

FDA revises safety information and limits use of Stryker Wingspan brain stent system

Fda.gov: Aug. 8, 2012 The U.S. Food and Drug Administration today approved changes to the labeling for the Stryker Wingspan Stent System, including the indications for use. These changes, which the FDA outlined in a safety communication also issued today, specify a more limited group of patients who may benefit from the system. In addition, the safety communication […]

Endothelin Receptor Antagonists for Aneurysmal Subarachnoid Hemorrhage

American Heart Association: August 7, 2012 Background and Purpose—Endothelin is considered to be a key mediator of vasospasm after subarachnoid hemorrhage. A meta-analysis of randomized trials on the effectiveness of endothelin receptor antagonists in subarachnoid hemorrhage has been published previously, but since then new major trials have been published. We present the results of a systematic […]

Quality of life of elderly ischaemic stroke patients one year after thrombolytic therapy. A comparison between patients with and without thrombolytic therapy

Biomedcentral.com: Published: 26 July 2012 An observational study to examine whether thrombolytic therapy in stroke patients realizes better quality of life outcomes compared to patients without thrombolytic therapy one year after stroke. We also examined whether daily functioning, mental functioning and activities improved after thrombolytic treatment. Subjects: A total of 88 stroke patients were interviewed at […]

Next-generation antithrombotics in ischemic stroke: preclinical perspective on ‘bleeding-free antithrombosis’

Journal of Cerebral Blood Flow & Metabolism: 7/18/12 Recombinant tissue plasminogen activator (tPA) is the only approved medication in acute ischemic stroke. However, <20% of all stroke patients receive tPA (Weimar et al, 2006), a situation mainly owed to the narrow treatment time window of 4.5 hours. Another significant limitation of tPA is bleeding-related adverse events. Moreover, as […]

Thrombolysis in ischemic strokes with no arterial occlusion

Onlinelibrary.wiley.com 8/1/12   Twelve million people develop ischemic stroke each year world over and 30–40% of them do not have arterial occlusions at presentation. Trials conducted to study the efficacy of thrombolytic drug reported better outcome with use of thrombolytic drug but none studied the subtypes of ischemic strokes specifically and adequately. The subgroups of […]

Retrospective Multicenter Study of Solitaire FR for Revascularization in the Treatment of Acute Ischemic Stroke

Stroke.ahajournals.org: July 31, 2012 The purpose of this study was to evaluate safety and efficacy of the Solitaire FR device in the treatment of patients with acute ischemic stroke secondary to large artery occlusion. Methods—We conducted a retrospective study of consecutive patients presenting with acute ischemic stroke treated with Solitaire FR as the first-line device to […]

Endovascular Therapy May Result In Significantly Better Outcomes Than Current Standard Treatment For Deadliest Strokes

Prnewswire.com: 7/2712 Results Announced at Society of NeuroInterventional Surgery (SNIS) 9th Annual Meeting SAN DIEGO, July 27, 2012 /PRNewswire-USNewswire/ — Endovascular therapy (EVT) is associated with significantly better treatment outcomes over traditional intravenous tPA (IVT) for patients suffering acute ischemic stroke resulting from blockages in the large vessels, or major “highways” of the brain, according to a study presented […]

Study May Transform Approach To Patient Selection For Minimally Invasive Stroke Treatment

Prnewswire.com: 7/24/12. The Society of Neurointerventional Surgery (SNIS) 9th Annual Meeting opened with study results which show that patients presenting with ischemic stroke may be successfully treated with endovascular or minimally invasive therapy well beyond the 8-hour treatment window today considered standard by most neurointerventional practitioners.  The multi-center study evaluated the use of computed tomography (CT) perfusion […]

Poststroke speech therapy ‘should be reorganized’

News-medical.net: 7/20/12. Results of the randomized ACT NoW trial show no benefit of “enhanced” over “everyday” communication therapy for patients with dysarthria resulting from stroke. Overall, communicative ability in the 170 patients in ACT NoW (Assessing Communication Therapy in the North West) improved over the study period, from a baseline average of 2.4 points on the […]

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