Therapies
Wednesday, July 11th, 2012
Onlinelibrary.wiley.com: 6/19/12. Many advances have been achieved in terms of understanding the molecular and cellular mechanisms of ischemic stroke. But thus far, clinically effective neuroprotectants remain elusive. In this minireview, we summarize the basics of ischemic cascades after stroke, covering neuronal death mechanisms, white matter pathophysiology, and inflammation with an emphasis on microglia. Translating promising mechanistic […]
Therapies
Wednesday, July 11th, 2012
Onlinelibrary.wiley.com: 6/19/12. The main driving force behind the assessment of novel pharmacological agents in animal models of stroke is to deliver new drugs to treat the human disease rather than to increase knowledge of stroke pathophysiology. There are numerous animal models of the ischaemic process and it appears that the same processes operate in humans. Yet, […]
Therapies
Wednesday, July 11th, 2012
Onlinelibrary.wiley.com: 5/28/12. Infections are common complications in patients with acute ischemic stroke; however, the pathophysiology of the stroke-induced immunodepression is still under debate. Although it has been shown that increased mortality and longer hospital stay are associated with the presence of poststroke infections, it remains unclear if early poststroke infections occurring in the first seven-days have […]
Therapies
Wednesday, July 11th, 2012
Onlinelibrary.wiley.com: 5/9/12. Our cohort included 1398 consecutive ischemic stroke patients treated with intravenous thrombolysis at the Helsinki University Central Hospital, years 1995–2010. We analyzed the patients according to baseline National Institutes of Health Stroke Scale: ≤2, 3–4, 5–6, and >6. In our institution, visualization of an artery occlusion or perfusion deficit is required for thrombolysis with […]
Therapies
Thursday, June 28th, 2012
Jama.jamanetwork.com: June 27, 2012, Vol 307, No. 24 Context Intravenous tissue plasminogen activator (tPA) is known to improve outcomes in ischemic stroke; however, patients receiving long-term chronic warfarin therapy may face an increased risk for intracranial hemorrhage when treated with tPA. Although current guidelines endorse administering intravenous tPA to warfarin-treated patients if their international normalized ratio […]
Therapies
Thursday, June 28th, 2012
A Sex-Based Meta-analysis Archinte.jamanetwork.com: June 25, 2012 Background The effect of statins on the prevention of cardiovascular events is well demonstrated. Whether this protective effect is equal for women and men remains less well established. Our objective was to evaluate if statin therapy is equally effective in decreasing recurrent cardiovascular events in women and men. Data […]
Therapies
Thursday, June 28th, 2012
Stroke.ahajournals.org: May 29, 2012 Revascularization of Collaterals for Hemodynamic Stroke Insight on Pathophysiology From the Carotid Occlusion Surgery Study Carotid atherosclerosis accounts for up to 15% of all strokes1 and approximately 15 000 to 20 000 have symptomatic carotid occlusions in the United States each year.2 Furthermore, recurrent ipsilateral stroke in unselected patients with carotid occlusion affects 2.1% […]
Therapies
Thursday, June 28th, 2012
Stroke.ahajournals.org: April 26, 2012. Background and Purpose—Time from symptom onset to hospital arrival is the most important factor in determining eligibility for intravenous tissue-type plasminogen activator. We used data from a large contemporary nationwide study to determine temporal trends in the proportions of patients arriving within time windows for potential acute ischemic stroke therapies. Methods—Trends in […]
Therapies
Friday, June 22nd, 2012
Stroke.ahajournals.org: June 19, 2012. Antiplatelet therapy nonresponse is associated with worse clinical outcomes. We studied the clinical outcomes associated with platelet function-guided modifications in antiplatelet therapy in patients with ischemic stroke or transient ischemic attack. Methods—From January 2005 to August 2007, 324 patients with ischemic stroke underwent platelet function testing using platelet aggregometry. Aspirin nonresponse was […]
Therapies
Friday, June 22nd, 2012
Stroke.ahajournals.org: June 19, 2012. The purpose of this study was to perform a meta-analysis of studies that investigated the effects of repetitive transcranial magnetic stimulation (rTMS) on upper limb motor function in patients with stroke. Methods—We searched for randomized controlled trials published between January 1990 and October 2011 in PubMed, Medline, Cochrane, and CINAHL using the […]
