Brain Bleed Size Affects Therapy in Afib Patients

By Ed Susman, Contributing Writer, MedPage Today, Published: April 27, 2012. NEW ORLEANS — The size of the brain bleed appears to determine which medications, if any, are given to atrial fibrillation patients after an intracerebral hemorrhage, a retrospective study showed. Patients with a brain bleed that averaged 2.39 cc were started on warfarin post bleed; those […]

A Randomized and Clinical Effectiveness Trial Comparing Two Pharmacogenetic Algorithms and Standard Care for Individualizing Warfarin Dosing (CoumaGen-II)

 American Heart Association: Correspondence to Jeffrey L. Anderson, MD, Intermountain Medical Center, Cardiovascular Department, 5121 S Cottonwood St, Murray, UT 84107-5701. March 19, 2012. Background—Warfarin is characterized by marked variations in individual dose requirements and a narrow therapeutic window. Pharmacogenetics (PG) could improve dosing efficiency and safety, but clinical trials evidence is meager. Methods and Results—A Randomized […]

Vascular Occlusion Enables Selecting Acute Ischemic Stroke Patients for Treatment With Desmoteplase

Stroke.ahajournals.org: April 3, 2012. Background and Purpose—Desmoteplase is a novel and highly fibrin-specific thrombolytic agent. Evidence of safety and efficacy was obtained in 2 phase II trials (Desmoteplase In Acute Ischemic Stroke [DIAS] and Desmoteplase for Acute Ischemic Stroke [DEDAS]). The DIAS-2 phase III trial did not replicate the positive phase II efficacy findings. Post […]

Jolt to brain aids language recovery

Science News: By Laura Sanders, Monday, April 2nd, 2012. CHICAGO — A brain zapping technique helps people recover language after a stroke, new research shows. The results may point to a better way for people to relearn how to talk after a brain injury. “I think this work is very promising,” said cognitive neuroscientist Roi Cohen Kadosh of […]

Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation

The Lancet Neurology: Prof Dirk M Hermann MD,  Prof Michael Chopp PhD b c. April 1, 2012. Recent laboratory findings suggest that it might be possible to promote cerebral plasticity and neurological recovery after stroke by use of exogenous pharmacological or cell-based treatments. Brain microvasculature and glial cells respond in concert to ischaemic stressors and treatment, creating an environment in which successful recovery […]

Three drugs, three similar names, some close calls

Philly.com: TUESDAY, APRIL 3, 2012. Watch out for dispensing mix-ups if you are taking any of the following medications: Ranexa, Prenexa and Pradaxa.  These drugs are all prescribed for different reasons although their names can look and/or sound very much alike. We’ve had some close calls reported to us lately through our National Medication Error Reporting Program, […]

Depression and Antidepressant Use After Stroke and Transient Ischemic Attack

Stroke.ahajournals.org: March 29, 2012. Background and Purpose—Patients with stroke and transient ischemic attack (TIA) often have comparable comorbidities, but it is unclear whether they have similar rates of depression or antidepressant use. Methods—This study was a secondary analysis of a prospective cohort registry that enrolled subjects from 2006 to 2008 in the United States. Depression […]

Intelligent, affordable rehab robot to help stroke patients

Rehabilitation is crucial after a stroke. Yet patients don’t always do their exercises because they’re boring or difficult to do at home. Physorg.com: March 27, 2012. But what if you could make them easy and fun? Enter University of Toronto Associate Professor Alex Mihailidis and his intelligent, table-top robot. “This new robot will help to […]

Physical Fitness Training for Patients With Stroke

Stroke.ahajournals.org: Miriam Brazzelli, BSc, PhD; David H. Saunders, BSc, MPhil, PhD; Carolyn A. Greig, BSc, MSc, PhD; Gillian E. Mead, MB, BChir, FRCP, MD, MA, March 15, 2012. Physical fitness is low after stroke and this may cause or exacerbate some common poststroke problems, including disability. It is not known whether improving physical fitness or participating […]

Impact of Emergency Department Transitions of Care on Thrombolytic Use in Acute Ischemic Stroke

Stroke.ahajournals.org: Olga P. Madej-Fermo, MD; Ilene Staff, PhD; Gil Fortunato, MBA; Lincoln Abbott, MD; Louise D. McCullough, MD, PhD, March 26, 2012. Background and Purpose—In-hospital mortality is higher for certain medical conditions based on the time of presentation to the emergency department. The primary goal of this study was to determine whether patients with acute ischemic […]

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