Common and Rare Variants in SCN10A Modulate the Risk of Atrial Fibrillation
Atrial Fibrillation Thursday, August 7th, 2014CIRCGENETICS: August 1, 2014
Background—Genome-wide association studies (GWAS) have shown that the common single nucleotide polymorphism (SNP) rs6800541 located in SCN10A, encoding the voltage-gated Nav1.8 sodium channel, is associated with PR−interval prolongation and atrial fibrillation (AF). SNP rs6800541 is in high linkage disequilibrium with the non-synonymous variant in SCN10A, rs6795970 (V1073A, r2=0.933). We aim to determine whether common and rare SCN10A variants are associated with early onset lone AF. Read More