Dabigatran Association With Higher Risk of Acute Coronary Events

Therapies Friday, March 16th, 2012

Meta-analysis of Noninferiority Randomized Controlled Trials

Archinte.ama-assn.org: Ken Uchino, MD; Adrian V. Hernandez, MD, PhD – March 12, 2012.

Background  The original RE-LY (Randomized Evaluation of Long-term Anticoagulant Therapy) trial suggested a small increased risk of myocardial infarction (MI) with the use of dabigatran etexilate vs warfarin in patients with atrial fibrillation. We systematically evaluated the risk of MI or acute coronary syndrome (ACS) with the use of dabigatran.

Methods  We searched PubMed, Scopus, and the Web of Science for randomized controlled trials of dabigatran that reported on MI or ACS as secondary outcomes. The fixed-effects Mantel-Haenszel (M-H) test was used to evaluate the effect of dabigatran on MI or ACS. We expressed the associations as odds ratios (ORs) and their 95% CIs. Read More

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