Does the sliding dichotomy result in higher powered clinical trials for stroke and traumatic brain injury research?

Clinical Trials Friday, October 5th, 2012

Ctj.sagepub.com: October 1, 2012

Recent research has proposed a new method for defining a favorable outcome in traumatic brain injury and stroke research.

Purpose This new method is called the sliding dichotomy, and it is suggested as a potential solution to the problem of underpowered clinical trials.

Methods We present a brief simulation study and graphical comparison of the power of each method to detect varying treatment effect sizes.

Results Simulations of a patient population similar to the National Acute Brain Injury Study: Hypothermia (NABISH) study indicate that the sliding dichotomy method does not result in higher power than traditional methods. read more

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