Emerging Therapy Critiques

Clinical Trials Saturday, December 14th, 2013

STROKEAHA: November 19, 2013

Early Short-Term Dual Antiplatelet Treatment for Stroke Prevention

The Clopidogrel in High-Risk Patients with Acute Nondisabling Cerebrovascular Events (CHANCE) trial tested the effect of early dual antiplatelet treatment for the prevention of secondary stroke within the first 90 days following a qualifying transient ischemic attack (TIA) or minor stroke in 5170 Chinese patients. The trial showed a significant reduction in secondary stroke in patients treated with dual antiplatelet therapy (hazard ratio, 0.68; 95% confidence interval, 0.57–0.81; P<0.001). There was no difference in the rate of moderate or severe hemorrhages (0.3% in both groups; P=0.73). Read more

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