Extra-Virgin Olive Oil Consumption Reduces Risk of Atrial Fibrillation: The PREDIMED Trial
Clinical Trials Monday, May 12th, 2014CIRCULATIONAHA: April 30, 2014
Background—The PREvención con DIeta MEDiterránea (PREDIMED) randomized primary prevention trial showed that a Mediterranean diet enriched with either extra-virgin olive oil or mixed nuts reduces incidence of stroke, myocardial infarction or cardiovascular mortality. We assessed the effect of these diets on the incidence of atrial fibrillation in the PREDIMED trial.
Methods and Results—Participants were randomly assigned to 1 of 3 diets: Mediterranean diet supplemented with extra-virgin olive oil, Mediterranean diet supplemented with mixed nuts, or advice to follow a low-fat diet (control group). Incident atrial fibrillation was adjudicated during follow-up by an events committee blinded to dietary group allocation. Among 6705 participants without prevalent atrial fibrillation at randomization, we observed 72 new cases of atrial fibrillation in the Mediterranean diet with extra-virgin olive oil group, 82 in the Mediterranean diet with mixed nuts group, and 92 in the control group, after median follow-up of 4.7 years. Read More
