Familial Aggregation of Lone Atrial Fibrillation in Young Persons

onlinejacc.org: 8/27/12

This study investigated whether an individual’s risk of developing lone atrial fibrillation (AF) before age 60 years is associated with lone AF in relatives.

Background  Genetic factors may play a role in the development of lone AF.

Methods  Using Danish national registers, a cohort was established of ∼4 million persons born between 1950 and 2008, and those with a family history of lone AF (AF without preceding cardiovascular/endocrine diagnoses) were identified. Individuals were followed up until the first diagnosis of lone AF. Poisson regression was used to estimate incidence rate ratios (IRRs). Read more