Genetic ACE I/D Polymorphism and Recurrence of Atrial Fibrillation after Catheter Ablation

Atrial Fibrillation Friday, July 26th, 2013

CIRCEP: July 22, 2013

Background—The ACE deletion allele, ACE D, is associated with increased cardiac ACE activity, cardiac fibrosis and adverse outcomes in cardiovascular disease and has been linked with failure of anti-AF drug treatment. This study tested the hypothesis that the angiotensin-converting enzyme gene (ACE) insertion/deletion (I/D) polymorphism associates with atrial fibrillation (AF) recurrence after catheter ablation.

Methods and Results—In 238 consecutive patients (69 % male, mean age 58 ± 11 years) undergoing catheter ablation of paroxysmal (59 %) or persistent (41 %) AF, the ACEinsertion/deletion [I/D] polymorphism was genotyped using polymerase chain reaction.  Read More

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