Impact of benzodiazepines on functional outcome and occurrence of pneumonia in stroke: evidence from VISTA

Therapies Friday, November 1st, 2013

International Journal of Stroke: OCT 22, 2013

Benzodiazepines have been proposed both as a neuroprotectant and risk factor for pneumonia in acute stroke.

Aims

We assessed the impact of benzodiazepine exposure on the modified Rankin scale score distribution at 90 days as well as pneumonia rates among patients registered in a trials archive.

Method

We used an age, baseline National Institutes of Health Stroke Score, and thrombolysis-rate adjusted Cochran–Mantel–Haenszel test to test significance (P) followed by proportional odds logistic regression analysis to estimate the odds ratios for improved modified Rankin scale score, and binary logistic regression to estimate the odds ratio for developing pneumonia. Read More

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