Net clinical benefit of new oral anticoagulants (dabigatran, rivaroxaban, apixaban) versus no treatment in a ‘real world’ atrial fibrillation population: A modelling analysis based on a nationwide cohort study

Therapies Friday, March 16th, 2012

Schattauer.de: A. Banerjee (1), D. A. Lane (1), C. Torp-Pedersen (2), G. Y. H. Lip (1), (1) University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham, UK; (2) Department of Cardiology, Copenhagen University Hospital – March 12, 2012. Gentofte, Denmark

Summary

The concept of net clinical benefit has been used to quantify the balance between risk of ischaemic stroke (IS) and risk of intracranial haemorrhage (ICH) with the use oral anticoagulant therapy (OAC) in the setting of non-valvular atrial fibrillation (AF), and has shown that patients at highest risk of stroke and thromboembolism gain the greatest benefit from OAC with warfarin. There are no data for the new OACs, that is, dabigatran, rivaroxaban and apixaban, as yet.  Read More

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