Non-steroidal anti-inflammatory drugs and the risk of atrial fibrillation: a population-based follow-up study

April 8, 2014

Abstract

Objective To investigate the association of non-steroidal anti-inflammatory drugs (NSAIDs) and the risk of atrial fibrillation in a prospective community-based follow-up study of elderly individuals with uniform case assessment and data on potential confounders.

Design Data came from the population-based follow-up study, the Rotterdam Study.

Participants The study comprised 8423 participants without atrial fibrillation at baseline.

Main outcome measures Atrial fibrillation was ascertained from ECG assessments as well as medical records. Use of NSAIDs was obtained from automated prescription records by linkage with participating pharmacies. We used Cox proportional hazards models to study the association between NSAID drug use and atrial fibrillation. Use of NSAIDs was included in the model as a time-varying variable.  Read More

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