Persistence With Therapy Among Patients Treated With Warfarin for Atrial Fibrillation
Atrial Fibrillation Thursday, October 25th, 2012JAMA Network: October 22, 2012
The major challenges of warfarin therapy relate to poor adherence and persistence, the need for regular monitoring, and the risk of hemorrhage. In clinical trials, persistence with warfarin treatment ranges from 75% to 79% at 1 year,1– 2 but persistence in clinical practice is thought to be poorer. Small observational studies suggest that approximately one-quarter of patients cease warfarin treatment within a year of initiation.3 – 4 To our knowledge, there are currently no large studies offering real-world estimates of persistence among warfarin users. Read more
