Regression analysis of ordinal stroke clinical trial outcomes: An application to the NINDS t-PA trial
Clinical Trials Thursday, June 27th, 2013Wiley: 6/27/13
Background
The modified Rankin scale (mRS) is the most common functional outcome assessed in stroke trials. The proportional odds model is commonly used to analyze this ordinal outcome but it requires a restrictive assumption that a single odds ratio applies across the entire outcome scale.
Aims
The study aims to model the effect of tissue-type plasminogen activator on ordinal mRS, test model assumptions, and compare fits and predictive ability of the statistical models. Read More