Risk of Stroke or Systemic Embolism in Atrial Fibrillation Patients Treated With Warfarin

Atrial Fibrillation Thursday, March 14th, 2013

​STROKEAHA: March 12, 2013

Background and Purpose—Although oral anticoagulants (OACs) are highly effective in reducing stroke risk in atrial fibrillation, some patients still sustain stroke despite being on an OAC. Our aim was to identify the risk factors that contribute to stroke risk in atrial fibrillation, although patients were taking OACs in a clinical trial setting.

Methods—We identified contemporary clinical trials that investigated OACs in patients with atrial fibrillation. Event rates per year from each study and pooled event rates and relative risks, all with a 95% confidence interval, were calculated. Statistical heterogeneity was assessed using the I2 test. Read more

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