Simulating sequential multiple assignment randomized trials to generate optimal personalized warfarin dosing strategies

Clinical Trials Wednesday, February 26th, 2014

Clin Trials: January 24, 2014

Background Due to the cost and complexity of conducting a sequential multiple assignment randomized trial (SMART), it is desirable to pre-define a small number of personalized regimes to study.

Purpose We proposed a simulation-based approach to studying personalized dosing strategies in contexts for which a therapeutic agent’s pharmacokinetic and pharmacodynamics properties are well understood. We take dosing of warfarin as a case study, as its properties are well understood. We consider a SMART in which there are five intervention points in which dosing may be modified, following a loading phase of treatment. Read more

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