Spatiotemporal Behaviour of High Dominant Frequency during Paroxysmal and Persistent Atrial Fibrillation in the Human Left Atrium

Atrial Fibrillation Friday, June 22nd, 2012

Circep.ahajournals.org: June 20, 2012.

Sites of high dominant frequency (DF) are thought to indicate the location of drivers of atrial fibrillation (AF) but characterisation of their spatiotemporal distribution and stability, critical to their relevance as targets for catheter ablation, requires simultaneous global mapping of the left atrium.

Methods and Results—Non-contact electrograms recorded simultaneously from 256 left atrial (LA) sites during spontaneous AF were analysed. After subtraction of the ventricular component, fast Fourier transform identified the DF at each site. Focal areas of high dominant frequency (DFpeak) were defined as those having a DF >20% above all neighbouring sites. Twenty-four patients with spontaneous AF (11 paroxysmal and 13 persistent) were studied. In paroxysmal AF, sites of DFpeak (mean DF 11.6±2.9 Hz) were observed in 100% of patients (present 65% of the mapping period).  Read more

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