Unexplained Early Neurological Deterioration After Intravenous Thrombolysis

Therapies Saturday, July 5th, 2014

STROKEAHA: May 29, 2014

Background and Purpose—Early neurological deterioration (END) after anterior circulation stroke is a serious clinical event strongly associated with poor outcome. Regarding specifically END occurring within 24 hours of intravenous recombinant tissue-type plasminogen activator, apart from definite causes such as symptomatic intracranial hemorrhage and malignant edema whose incidence, predictors, and clinical management are well established, little is known about END without clear mechanism (ENDunexplained).

Methods—We analyzed 309 consecutive patients thrombolysed intravenously ≤4.5 hours from onset of anterior circulation stroke.  Read more

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