Gastroesophageal Reflux Disease and Atrial Fibrillation: A Nationwide Population-Based Stud

Plosone: 10/15/12 Precise mechanisms of atrial fibrillation (AF) are uncertain, but their association with esophageal disorders has been recently proposed. The association between gastroesophageal reflux disease (GERD), the most common gastroesophageal disorder, and AF remains undetermined. We therefore aimed to investigate the association between GERD and later development of AF. Read More

Basic Science for the Clinical Electrophysiologist

American Heart Association, Inc:  October 1, 2012 Atrial fibrillation (AF) is the most common sustained arrhythmia encountered in clinical practice, affecting 1.5% to 2.0% of the population in the developed world. The lifetime risk for the development of AF is ≈1 in 4 men and women aged ≥40 years.1,2 A 2.5- to 3.0-fold increase in the […]

Long-Standing Persistent Atrial Fibrillation

The Metastatic Cancer of Electrophysiology⁎⁎ Since the first reports of ablation therapy being used to treat atrial fibrillation, the field has exploded with studies, new techniques, and new technologies (1). It is no wonder that such fervor is associated with this topic. Our medical options to maintain sinus rhythm have been generally poorly effective, riddled […]

Atrial fibrillation: the scope of the problem

Atrial fibrillation: the scope of the problem 29 Aug 08:30 – 10:00 Atrial fibrillation (AF) Abstract Session Tallinn – Village 7 Chairpersons: Dobromir DOBREV (Mannheim, DE), Antonio MADRID (Madrid, ES) Presentations list Time FP Nr Title Speakers Related documents 08:30 5296 Female gender and risk of stroke in atrial fibrillation: a nationwide cohort study Anders MIKKELSEN […]

Assessing the Risk of Bleeding in Patients With Atrial Fibrillation

The Loire Valley Atrial Fibrillation Project Management decisions for thromboprophylaxis in atrial fibrillation need to balance the risk of stroke against serious hemorrhage. The objective of the present analysis is to compare the Hypertension, Abnormal renal/liver function, Stroke, Bleeding history or predisposition, Labile international normalized ratio, Elderly (>65 years), Drugs/alcohol concomitantly (HAS-BLED) score against other […]

Clinical Trials: Around Half of New Treatments Perform Better Than Existing Treatments, Review Finds

ScienceDaily (Oct. 16, 2012) — On average, new treatments perform better in clinical trials only slightly more often than existing treatments, according to a new systematic review published in The Cochrane Library. The fact that experimental treatments are not more effective may seem disappointing, but the authors of the review say their findings satisfy an important ethical […]

Estimating treatment effects in observational studies

Neurology: October 17, 2012 Randomized controlled trials are required to determine the effectiveness and safety of medical therapies for clinical use. However, observational studies are used frequently to evaluate treatment effects in a number of situations, such as postmarketing safety evaluations of medications or in situations where clinical trials are not feasible.1 Unlike randomized controlled trials, where […]

The role of statin therapy in the prevention of atrial fibrillation: a meta-analysis of randomized controlled trials

John Wiley & Sons, Inc.: OCT 9, 2012 WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Atrial fibrillation (AF) is the most common clinically significant cardiac arrhythmia, and AF is associated with relatively higher all-cause mortality in both men and women. • However, there are limited treatment options for AF. • Statins are hypothesized to have a benefit against […]

Aggregate-data estimation of an individual patient data linear random effects meta-analysis with a patient covariate-treatment interaction term

Biostatistics: September 21, 2012 Individual patient-data meta-analysis of randomized controlled trials is the gold standard for investigating how patient factors modify the effectiveness of treatment. Because participant data from primary studies might not be available, reliable alternatives using published data are needed. In this paper, I show that the maximum likelihood estimates of a participant-level linear […]

Single-Ring Posterior Left Atrial (Box) Isolation Results in a Different Mode of Recurrence Compared With Wide Antral Pulmonary Vein Isolation on Long-Term Follow-Up

Longer Atrial Fibrillation–Free Survival Time but Similar Survival Time Free of Any Atrial Arrhythmia American Heart Association, Inc.: September 12, 2012 Electric isolation of the pulmonary veins and posterior left atrium with a single ring of radiofrequency lesions (single-ring isolation [SRI]) may result in fewer atrial fibrillation (AF) recurrences than wide antral pulmonary vein isolation (wide […]

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