Reperfusion Therapy in Unclear-Onset Stroke Based on MRI Evaluation

Stroke AHA Journals: October 23, 2012 Unclear-onset strokes are generally excluded from time-based thrombolytic therapy. We examined the safety and feasibility of magnetic resonance imaging-based reperfusion therapy in unclear-onset stroke. Methods—This prospective, multicenter, single-arm study screened consecutive unclear-onset stroke patients within 6 hours of symptom detection. Patients with perfusion-diffusion mismatch >20% and negative or subtle fluid-attenuated […]

Risk Factors for Intracranial Hemorrhage in Acute Ischemic Stroke Patients Treated With Recombinant Tissue Plasminogen Activator

Stroke AHA Journals: September 20, 2012 A Systematic Review and Meta-Analysis of 55 Studies Recombinant tissue plasminogen activator (rtPA) is an effective treatment for acute ischemic stroke but is associated with an increased risk of intracranial hemorrhage (ICH). We sought to identify the risk factors for ICH with a systematic review of the published literature. Methods—We […]

Preventive Antibiotics in Acute Stroke

Stroke AHA Journals: September 13, 2012 Summary of a Cochrane Systematic Review and Meta-Analysis Stroke is a major cause of morbidity and mortality worldwide. One of the major complications in the acute phase of stroke is infection; especially pneumonia and urinary tract infection occur often. Poststroke infections are strongly associated with poor outcome. Preventive antibiotic therapy […]

Poststroke Spasticity Management

Stroke AHA Journals: September 13, 2012 Poststroke spasticity (PSS) is a common complication associated with other signs and symptoms of the upper motor neuron syndrome, including agonist/antagonist co-contraction, weakness, and lack of coordination. Together, they result in impairments and functional problems that can predispose to costly complications. The goal of PSS management should take into consideration […]

Prevention of Vascular Cognitive Impairment

Stroke AHA Journals: August 30, 2012 Dementia has become a pressing health issue, with numbers steadily increasing. Vascular injury is the second most common cause of dementia after Alzheimer disease (AD) and a defining feature of vascular cognitive impairment (VCI), which encompasses the full range from vascular dementia (VaD) to mild cognitive impairment of vascular origin.1,2 […]

Relationship Between Time from Ambulance Call to Arrival at Emergency Center and Level of Consciousness at Admission in Severe Stroke Patients

Ambulance

Cambridge Journals: October 24, 2012 Timely access to acute medical treatment can be critical for patients suffering from severe stroke. Little information is available about the impact of prehospital delays on the clinical conditions of stroke patients, but it is possible that prehospital delays lead to neurological deterioration. The aim of this study was to […]

What Causes Disability After Transient Ischemic Attack and Minor Stroke?

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Stroke AHA Journals: September 13, 2012   Minor stroke and transient ischemic attack portend a significant risk of disability. Three possible mechanisms for this include disability not captured by the National Institutes of Health Stroke Scale, symptom progression, or recurrent stroke. We sought to assess the relative impact of these mechanisms on disability in a population […]

Higher Stroke Unit Volume Associated With Improved Quality of Early Stroke Care and Reduced Length of Stay

Stroke AHA Journals: September 13, 2012 Specialized stroke unit care improves outcome among patients with stroke, but it is unclear whether there are any scale advantages in costs and clinical outcome from treating a larger number of patients. We examined whether the case volume in stroke units was associated with quality of early stroke care, mortality, […]

How Are Household Economic Circumstances Affected After a Stroke? The Psychosocial Outcomes In StrokE (POISE) Study

Stroke AHA Journals: September 4, 2012 Stroke is associated with severe economic consequences. This is the first study to investigate in younger survivors the household economic burden of stroke. Methods—A multicenter, 3-year prospective cohort study was conducted of younger (18–65 years) survivors in Australia. Pre- and poststroke patterns of income and hardship were evaluated and multivariable […]

A Risk Score Based on Get With the Guidelines–Stroke Program Data Works in Patients With Acute Ischemic Stroke in China

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Stroke AHA Journals: October 4, 2012 There are few validated models for prediction of in-hospital mortality after acute ischemic stroke. In 2010, Smith et al developed and internally validated models for predicting in-hospital mortality based on Get With the Guidelines–Stroke program data. We demonstrate the applicability of this Get With the Guidelines risk model in Chinese […]

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