Impact of Early Blood Pressure Variability on Stroke Outcomes After Thrombolysis

STROKEAHA: January 17, 2013 Background and Purpose—The present study determines associations between early blood pressure (BP) variability and stroke outcomes after intravenous thrombolysis. Methods—In 527 stroke patients receiving intravenous alteplase (0.6 mg/kg), BP was measured 8 times within the first 25 hours. BP variability was determined as ΔBP (maximum-minimum), standard deviation (SD), coefficient of variation, and […]

Concerns about medications mediate the association of posttraumatic stress disorder with adherence to medication in stroke survivors

Wiley: JAN 7, 2013 Objectives Post-traumatic stress disorder (PTSD) can be a consequence of acute medical events and has been associated with non-adherence to medications. We tested whether increased concerns about medications could explain the association between PTSD and non-adherence to medication in stroke survivors. Design We surveyed 535 participants aged 40 years or older who had […]

An Observational Study of Thrombolysis Outcomes in Wake-Up Ischemic Stroke Patients

STROKEAHA: January 3, 2013 Background and Purpose—Wake-up ischemic stroke (WUIS) patients are not eligible for thrombolysis; the a priori hypothesis was that thrombolysis of selected WUIS patients who meet clinical and imaging criteria for treatment is associated with better outcomes. Methods—The sample consisted of consecutive WUIS patients who fulfilled predefined criteria: (1) were last seen normal […]

Treatment Targets in Atrial Fibrillation

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“Is Feeling Better Good Enough?”⁎⁎ Clinical Research: January 2013 Atrial fibrillation (AF) is the most common sustained arrhythmia necessitating medical therapy. The majority of AF patients have associated cardiovascular comorbidities that increase the risk of negative cardiovascular outcomes, including excess morbidity, hospitalizations, and mortality ((1),2). Data assessing a disease management strategy of rate versus rhythm control […]

Multiple Biomarkers for the Prediction of Ischemic Stroke

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ATVBAHA: anuary 17, 2013 Objective—To simultaneously evaluate 14 biomarkers from distinct biological pathways for risk prediction of ischemic stroke, including biomarkers of hemostasis, inflammation, and endothelial activation as well as chemokines and adipocytokines. Methods and Results—The Prospective Epidemiological Study on Myocardial Infarction (PRIME) is a cohort of 9771 healthy men 50 to 59 years of age […]

Socioeconomic Status and Care After Stroke

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Results From the Registry of the Canadian Stroke Network STROKEAHA: January 15, 2013 Background and Purpose—Socioeconomic status is inversely associated with mortality after stroke; however, the reasons behind this finding are not well-understood. We undertook a study to determine whether posthospitalization care and medication adherence vary with neighborhood income. Methods—We conducted a cohort study of 11 […]

Stroke Severity as Well as Time Should Determine Stroke Patient Triage

STROKEAHA: January 3, 2013 The National Institute of Neurological Disorders and Stroke studies,1 published in 1995, demonstrated for the first time that in patients selected by clinical and noncontrast computed tomography criteria, intravenous TPA (IV tissue plasminogen activator) resulted in improved outcomes compared with standard treatment. Since that time, safe and quick delivery of IV TPA has […]

Cannabis-related Stroke

STROKEAHA: December 27, 2012 Myth or Reality? Cannabis, which is the most widely used recreational substance in the world, is considered by many consumers as safe with few negative side effects.1 This opinion is somehow strengthened by the fact that cannabis was also shown to have therapeutic applications.2 Cannabis is obtained from the plant Cannabis sativa and its varieties Cannabis indica and Cannabis […]

Stroke Risk Calculators in the Era of Electronic Health Records Linked to Administrative Databases

STROKEAHA: November 29, 2012 Medicine is a science of uncertainty and an art of probability. —Sir William Osler, 1904 Electronic health records (EHRs) linked to administrative databases can unlock the potential of clinical data by overcoming limitations of current cohort-derived risk calculators. EHRs can facilitate implementation of risk-based approaches, whereas current manual or web-based risk calculators […]

Statins Therapy Can Reduce the Risk of Atrial Fibrillation in Patients with Acute Coronary Syndrome: A Meta-Analysis

Int J Med Sci: 1/16/13 Background: It is a controversy whether statins therapy could be beneficial for the occurrence of atrial fibrillation (AF) in acute coronary syndrome (ACS). To clarify this problem, we performed a meta-analysis with the currently published literatures. Methods: The electronic databases were searched to obtain relevant trials which met the inclusion criteria […]

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