Atrial Fibrillation
Wednesday, April 17th, 2013
J Am Coll Cardiology: April 1, 2013 Objective To assess the efficacy and safety in an ‘everyday clinical practice’ population of anticoagulant-naïve patients with atrial fibrillation (AF) treated with dabigatran etexilate following its post-approval availability in Denmark, compared to warfarin. Background Concerns have been raised about an excess of bleeding events or myocardial infarction amongst patients treated […]
Atrial Fibrillation
Wednesday, April 17th, 2013
J Am Coll Cardiology: April 1, 2013 Objective To assess the prognostic value of N-terminal pro-B-type natriuretic peptide (NT-proBNP) in patients with atrial fibrillation (AF) enrolled in the ARISTOTLE trial, and the treatment effect of apixaban according to NT-proBNP levels. Background Natriuretic peptides are associated with mortality and cardiovascular events in several cardiac diseases. Read more
Atrial Fibrillation
Wednesday, April 17th, 2013
International Journal of Cardiology: March 1, 2013 Background Improvement of oral hygiene through dental scaling was associated with a decreased risk of cardiovascular events. The goal of the present study was to investigate whether dental scaling can reduce the risk of atrial fibrillation (AF). Methods In year 2000, a total of 28,909 subjects who were age […]
Clinical Trials
Wednesday, April 17th, 2013
AHA Stroke: April 11, 2013 Stroke is the fourth leading cause of death in the United States, and it is a major cause of long-term disabil- ity and reduced quality of life for hundreds of thousands of Americans. Over the past decades, teams of National Institute of Neurological Disorders and Stroke (NINDS)–funded clini- cal trialists have […]
Clinical Trials
Wednesday, April 17th, 2013
Trials: April 11, 2013 Background Traditionally in acute stroke clinical trials, the primary clinical outcome employed is a dichotomized modified Rankin Scale (mRS). New statistical methods, such as responder analysis, are being used in stroke studies to address the concern that baseline prognostic variables, such as stroke severity, impact the likelihood of a successful outcome. Responder […]
Clinical Trials
Wednesday, April 17th, 2013
CIRCULATIONAHA: April 9, 2013, Background—This study examined the impact of different ablation strategies on AF recurrence and quality of life (QoL) in coexistent atrial fibrillation (AF) and flutter (AFL). Methods and Results—Three-hundred sixty enrolled patients with documented AF and AFL were blinded and randomized to group 1: AF±AFL ablation (n=182) or Group 2: AFL ablation only […]
Clinical Trials
Wednesday, April 17th, 2013
J NeuroIntervent Surgery: April 6, 2013 Objective There are few data regarding the effect of the Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis (SAMMPRIS) trial results on the management of intracranial atherosclerotic disease (ICAD). We sought to understand the impact of the SAMMPRIS trial on current ICAD clinical practices and future trial […]
Clinical Trials
Wednesday, April 17th, 2013
Biostatistics: March 21, 2013 Modern medicine has graduated from broad spectrum treatments to targeted therapeutics. New drugs recognize the recently discovered heterogeneity of many diseases previously considered to be fairly homogeneous. These treatments attack specific genetic pathways which are only dysregulated in some smaller subset of patients with the disease. Often this subset is only rudimentarily […]
Therapies
Wednesday, April 17th, 2013
J NeuroIntervent Surgery: April 11, 2012 Background Recent evidence indicates that multidisciplinary care improves patient outcomes in cerebrovascular (CV) disease. A multidisciplinary integrated CV program was recently instituted at a high-volume tertiary referral center, providing the opportunity to evaluate patient outcomes before and after its introduction. Objective To evaluate outcomes after treatment of patients with intracranial aneurysm in […]
Therapies
Wednesday, April 17th, 2013
The Lancet Neurology: April 1, 2013 Little is known about the pathophysiology of intracerebral haemorrhage that occurs during anticoagulant treatment. In observational studies, investigators have reported larger haematoma volumes and worse functional outcome in these patients than in those with intracerebral haemorrhage and a normal coagulation status. The need to prevent extensive haematoma enlargement by rapid […]
