Atrial Fibrillation
Thursday, June 27th, 2013
News-medical: June 25, 2013 Using catheter ablation to create complete linear lesions around pulmonary veins, proved more effective than the creation of incomplete lesions in preventing recurrence of atrial fibrillation (AF), reports the GAP-AF study. The study, presented today in the Late Breaking Clinical Trials session I at the EHRA EUROPACE 2013 meeting in Athens, Greece, represents the first time […]
Atrial Fibrillation
Thursday, June 27th, 2013
Neurology: 6/26/13 Objective: Antiplatelets are recommended for secondary prevention in patients with cryptogenic stroke; however, some patients may present with a cardioembolic source that has not been detected, which may modify the treatment. Because high pro–brain natriuretic peptide (BNP) levels are associated with cardioembolic stroke, our objective was to determine whether pro-BNP levels in the acute […]
Atrial Fibrillation
Thursday, June 27th, 2013
JAHA: June 19, 2013 A New Risk Scheme to Predict Ischemic Stroke and Other Thromboembolism in Atrial Fibrillation: The ATRIA Study Stroke Risk Score Background More accurate and reliable stroke risk prediction tools are needed to optimize anticoagulation decision making in patients with atrial fibrillation (AF). We developed a new AF stroke prediction model using the […]
Clinical Trials
Thursday, June 27th, 2013
Wiley: 6/27/13 Background The modified Rankin scale (mRS) is the most common functional outcome assessed in stroke trials. The proportional odds model is commonly used to analyze this ordinal outcome but it requires a restrictive assumption that a single odds ratio applies across the entire outcome scale. Aims The study aims to model the effect of […]
Clinical Trials
Thursday, June 27th, 2013
NEJM: 6/26/13 BACKGROUND Stroke is common during the first few weeks after a transient ischemic attack (TIA) or minor ischemic stroke. Combination therapy with clopidogrel and aspirin may provide greater protection against subsequent stroke than aspirin alone. METHODS In a randomized, double-blind, placebo-controlled trial conducted at 114 centers in China, we randomly assigned 5170 patients […]
Clinical Trials
Thursday, June 27th, 2013
The Lancet Neurology: June 21, 2013 Background Few data are available from randomised trials about the effect of thrombolysis with alteplase on long-term functional outcome in patients who have had acute ischaemic stroke and no trial has reported effects on health-related quality of life. A secondary objective of the third International Stroke Trial (IST-3) was […]
Clinical Trials
Thursday, June 27th, 2013
Pharma Times | JUNE 20, 2013 There have been significant improvements over the last eight years in public perceptions of clinical-trial safety as well as trust in the motives of clinical research professionals, a new international study has found. In the online survey conducted between January and March 2013 by US-based non-profit the Center for Information […]
Clinical Trials
Thursday, June 27th, 2013
AHA: May 28, 2013 Stroke is the third most common cause of death and the most common cause of acquired adult disability in developed countries.1 Motor impairment is common after stroke, and a critical factor influencing the patient’s ability to live independently.2,3 The neurobiological mechanisms of plasticity and spontaneous recovery during the initial days and weeks after […]
Therapies
Thursday, June 27th, 2013
AHA: 7/1/13 In a recent systematic review and meta-analysis, the overall prevalence of unruptured intracranial aneurysms (IAs) is estimated as 3.2%.1 The prevalence of IAs is higher in patients with autosomal dominant polycystic kidney disease or a positive family history of IAs of subarachnoid hemorrhage (SAH).1 From the same review, the size of unruptured IAs is <5 […]
Therapies
Thursday, June 27th, 2013
Diabetes Care: July 1, 2013 OBJECTIVE Few tools are available to evaluate clinical outcomes and response to thrombolysis (tPA) in stroke patients with diabetes. We explored how the iScore (www.sorcan.ca/iscore), a validated risk score, predicts clinical outcomes in stroke patients with and without diabetes. RESEARCH DESIGN AND METHODS We applied the iScore to stroke patients presenting to stroke […]
