Results of Intravenous Thrombolysis Within 4.5 to 6 Hours and Updated Results Within 3 to 4.5 Hours of Onset of Acute Ischemic Stroke Recorded in the Safe Implementation of Treatment in Stroke International Stroke Thrombolysis Register (SITS-ISTR) An Observational Study

  JAMA Neurol: 7/1/13 Importance  Pooled analysis of randomized controlled trials of intravenous thrombolysis shows no statistically significant benefit beyond 4.5 hours, with the possible advantage perhaps offset by risk.   Objective  To compare the outcomes of patients who were treated within 4.5 to 6 hours or within 3 to 4.5 hours of the onset of an ischemic […]

Epidemiology of stroke and its subtypes in Chinese vs white populations

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Neurology: July 16, 2013 Objective: We aimed to systematically assess the evidence for differences in the incidence of stroke and distribution of its subtypes in Chinese compared with white populations. Methods: We comprehensively sought studies conducted since 1990 in Chinese populations of 1) first-ever stroke incidence (community-based studies only), and 2) pathologic types/subtypes of stroke (hospital- or community-based […]

Gene Signature Predicts Aspirin Resistance

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National Institutes of Health: July 16th, 2013 About 60 million Americans take an aspirin a day to reduce the risk of strokes and heart attacks. But for 10 to 30% of those who follow this recommendation, this preventive therapy turns out not to offer any protection. An NIH-funded team, based at Duke University Medical Center, has […]

Overlap of Diseases Underlying Ischemic Stroke

  STROKEAHA: 7/16/13 The ASCOD Phenotyping   Background and Purpose—ASCOD phenotyping (A, atherosclerosis; S, small vessel disease; C, cardiac pathology; O, other causes; and D, dissection) assigns a degree of likelihood to every potential cause (1 for potentially causal, 2 for causality is uncertain, 3 for unlikely causal but disease is present, 0 for absence of […]

Adherence to antihypertensive therapy prior to the first presentation of stroke in hypertensive adults: population-based study

Eur Heart J : 7/16/13 Aims Antihypertensive drug therapy is a major strategy of stroke prevention among hypertensive patients. The aim of this study was to estimate the excess risk of stroke associated with non-adherence to antihypertensive drug therapy among hypertensive patients. Methods and results We conducted a population-based study using records from Finnish national registers for 1 January […]

Antithrombotic drugs and risk of hemorrhagic stroke in the general population

Neurology: 7/10/13 Objective: To investigate the relationship between hemorrhagic stroke and use of antiplatelets and warfarin using data from The Health Improvement Network. Methods: A total of 1,797 incident cases of intracerebral hemorrhage (ICH) and 1,340 of subarachnoid hemorrhage (SAH) were ascertained. Density-based sampling was used to select 10,000 controls free from hemorrhagic stroke. Risk of hemorrhagic stroke […]

Outcomes for people with atrial fibrillation in an Australian national audit of stroke care

Wiley: JULY 9, 2013 Atrial fibrillation is associated with poorer outcomes poststroke. It is unclear how the quality of stroke care in hospitals influences outcomes in these patients. Aims The study aims to compare outcomes in stroke patients with and without atrial fibrillation and identify hospital processes of care associated with poor outcomes. Methods Data were […]

National Minority Quality Forum Announces Addition of PhRMA to Collaboration to Increase Diversity in Clinical Trials

FOR IMMEDIATE RELEASE Contact: Gretchen C. Wartman Monday, July 08, 2013 Telephone: 202-223-7560   The National Minority Quality Forum (The Forum) announces that the Pharmaceutical Research and Manufacturers of America (PhRMA) has joined The Forum’s collaboration with Microsoft to launch The National Clinical Trial Network (NCTN). PhRMA represents the country’s leading innovative biopharmaceutical research and […]

Results expression for tests used to measure the anticoagulant effect of new oral anticoagulants

Thrombosis Journal: 6/28/2013 Results of clotting tests used to measure the effect of old and new antithrombotic drugs can be expressed in different ways and this is considered as one of the sources of variability to explain the differences of results obtained for the same patient plasma when tested in different laboratories. This is particularly important […]

Are clinical trial data shared sufficiently today? Yes

BMJ: 7/9/13 he AllTrials campaign asks for all trials to be registered and their results published.Ben Goldacre (doi:10.1136/bmj.f1880) says we need the evidence to make informed decisions about medicines. John Castellani says mandatory disclosure could affect patient privacy, stifle discovery, and allow competitors or unscrupulous actors to use the information Clinical trials are essential for the successful development […]

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