Clinical Trials
Monday, September 23rd, 2013
STROKEAHA: September 19, 2013 A Retrospective Analysis of Clinical Trial Data Background and Purpose—Quality of life (QoL) is important to stroke survivors yet is often recorded as a secondary measure in acute stroke randomized controlled trials. We examined whether commonly used stroke outcome measures captured aspects of QoL. Methods—We examined primary outcomes by National Institutes […]
Clinical Trials
Monday, September 23rd, 2013
STROKEAHA: September 19, 2013 Background and Purpose—Use of the modified Rankin scale (mRS) in multicenter trials may be limited by interobserver variability. We assessed the effect of this on trial power and developed a novel group adjudication approach. Methods—We generated power and sample size estimates from simulated trials modeled with varying mRS reliability. We conducted […]
Clinical Trials
Monday, September 23rd, 2013
Nature: September 18, 2013 Mahesh P Kate, Mikkel B Hansen, Kim Mouridsen, Leif Østergaard, Victor Choi, Bronwen E Gould, Rebecca McCourt, Michael D Hill, Andrew M Demchuk, Shelagh B Coutts, Dariush Dowlatshahi, Derek J Emery, Brian H Buck, Kenneth S Butcher and for the ICHADAPT Investigators Abstract Blood pressure (BP) reduction after intracerebral hemorrhage (ICH) is controversial, because of concerns that this may cause critical reductions in perihematoma perfusion and thereby […]
Clinical Trials
Monday, September 23rd, 2013
JACC: September 1, 2013 Objectives To test the hypothesis that a specific bleeding risk score, HAS-BLED was better at predicting major bleeding compared to CHADS2 and CHA2DS2-VASc in anticoagulated atrial fibrillation (AF) patients. Background The CHADS2 and CHA2DS2-VASc scores are well-validated stroke risk prediction scores for AF, but are also associated with increased bleeding and mortality. Methods We […]
Therapies
Monday, September 23rd, 2013
STROKEAHA: September 19, 2013 Background and Purpose—There is evidence that high-volume hospitals may produce better patient outcomes. We aimed to identify whether there were any associations between hospital thrombolysis volume and speed of thrombolysis (tissue-type plasminogen activator [tPA]) administration in patients with ischemic stroke. Read more
Therapies
Monday, September 23rd, 2013
NeuroIntervent Surg: 9/19/13 Outcomes from endovascular therapy for acute stroke are time dependent. Delays in the administration of this therapy have not been extensively studied and no performance benchmarks have been established. There are limited data on the complex factors that can affect these delays. In this review, we discuss the existing literature on the […]
Therapies
Monday, September 23rd, 2013
J Am Heart Assoc.: 9/17/13 Background Intravenous tissue plasminogen activator (tPA) is an effective treatment for acute ischemic stroke if administered within a few hours of stroke onset. Because of this time restriction, tPA administration remains infrequent. Ambulance use is an effective strategy for increasing tPA administration but may be influenced by geographical factors. The objectives […]
News
Monday, September 23rd, 2013
STROKEAHA: September 17, 2013 Background and Purpose—Socioeconomic status and acculturation may modify the association between ethnicity and hypertension treatment before stroke. We assessed prestroke treatment of hypertension by ethnicity, education (proxy for socioeconomic status), and English proficiency (EP; proxy for acculturation) in a population-based stroke surveillance project. Methods—Among 763 patients with first-ever stroke aged ≥45 […]
News
Monday, September 23rd, 2013
AHA: Cardiovascular Quality and Outcomes 9/1/13 Background—Substantial efforts over the past decade have increased rates of intravenous tissue plasminogen activator (tPA) use in the United States. We sought to determine changes in patient characteristics and rates of tPA use over time among hospitalized acute ischemic stroke (AIS) patients. Methods and Results—We analyzed all AIS patients […]
News
Monday, September 23rd, 2013
ScienceDirect: 8/23/13 Research in the last three decades has shown that negative neighborhood factors such as neighborhood violence, noise, traffic, litter, low neighborhood socioeconomic status, and poor air quality increase the risk of poor health. Fewer studies have examined the potential protective effect that neighborhood factors can have on health, particularly stroke. We examined whether higher […]
