Clinical Trials
Tuesday, February 18th, 2014
STROKEAHA: January 16, 2014 Background and Purpose—Hypothermia improves outcome in resuscitated patients and newborns with hypoxic brain injury. We studied the safety and feasibility of mild hypothermia in awake patients with stroke after intravenous thrombolysis. Methods—Patients were randomized 1:1 to mild hypothermia (35°C) or to standard stroke unit care within 6 hours of symptom onset. Hypothermia […]
Clinical Trials
Tuesday, February 18th, 2014
The Lancet Neurology: February 2014 Background Arm hemiparesis secondary to stroke is common and disabling. We aimed to assess whether robotic training of an affected arm with ARMin—an exoskeleton robot that allows task-specific training in three dimensions—reduces motor impairment more effectively than does conventional therapy. Methods In a prospective, multicentre, parallel-group randomised trial, we enrolled patients […]
Clinical Trials
Tuesday, February 18th, 2014
STROKEAHA: December 26, 2013 Many articles in Stroke have considered good statistical practice for adequate planning and high-power analysis for stroke trials. They have discussed which test may be adequate and powerful, proposals for an effect size measure, and proposals for defining number needed to treat (NNT) based on an ordinal scale (see online-only Data Supplement for citations). […]
Clinical Trials
Tuesday, February 18th, 2014
STROKEAHA: December 24, 2013 Cell-based therapy continues to grow as a new field to explore investigational treatments for stroke. Leaders from academia and industry convened an inaugural meeting in 2007 with members of the National Institutes of Health and Food and Drug Administration (FDA) to generate consensus-based guidelines on the development of cell therapies for stroke, […]
Therapies
Tuesday, February 18th, 2014
STROKEAHA: January 23, 2014 Physical fitness is low after stroke and this may cause or exacerbate some common poststroke problems, including disability. It is not known whether physical fitness training after stroke reduces death, disability, or dependency. Objectives: The primary aims of this review1 were to determine whether physical fitness training (cardiorespiratory training and resistance […]
Therapies
Tuesday, February 18th, 2014
STROKEAHA: January 16, 2014 Intravenous thrombolysis with tissue plasminogen activator (tPA) is the only therapy proven to improve outcome in ischemic stroke. Studies of intravenous thrombolysis show that response to therapy is time-dependent; the sooner the patients receive tPA, the better the chance of good outcome.1 The required brain imaging before tPA administration delays the initiation of […]
Therapies
Tuesday, February 18th, 2014
STROKEAHA: January 16, 2014 The simultaneous publication of 3 randomized control trials comparing intravenous thrombolysis therapy to the endovascular treatment (EVT) of acute ischemic stroke might have lead to the erroneous conclusion that EVT has no place in the management of acute ischemic stroke.1–3However, careful analysis of these studies shows that these reports have shortcomings because […]
Therapies
Tuesday, February 18th, 2014
STROKEAHA: January 7, 2014 Current guidelines advocate intravenous thrombolysis for patients with ischemic stroke <4.5 hours from onset without additional imaging beyond noncontrast computed tomography (CT) of the brain.1 Rapid administration of intravenous tissue-type plasminogen activator (IV-tPA) will reduce disability. Treatment of patients within 3 hours has an odds ratio of 1.53 (95% confidence interval, 1.26–1.86) for […]
Therapies
Tuesday, February 18th, 2014
STROKEAHA: December 24, 2013 Organized stroke unit care is a form of care provided in hospital by nurses, doctors, and therapists who specialize in looking after patients with stroke and work as a coordinated team. This care has been provided in different ways, including: (1) a ward dedicated to patients with stroke; (2) through a mobile […]
Guidelines
Tuesday, February 18th, 2014
American College of Physicians: January 28, 2014 Description: In November 2013, the American College of Cardiology and American Heart Association (ACC/AHA) released a clinical practice guideline on the treatment of blood cholesterol to reduce cardiovascular risk in adults. This synopsis summarizes the major recommendations. Methods: In 2008, the National Heart, Lung, and Blood Institute convened the Adult Treatment […]
