Clinical Trials
Sunday, March 2nd, 2014
Experimental & Translational Stroke Medicine: February 7, 2014 Background Efficacy of neuroprotective treatments for ischemic stroke was not convincingly demonstrated in clinical phase III trials so far, whereas some preceding early phase studies found neuroprotection to be beneficial. We aimed to determine the frequency with which phase III studies are preceded by positive early phase studies, […]
Clinical Trials
Sunday, March 2nd, 2014
STROKEAHA: January 30, 2014 Background and Purpose—Improving actionable stroke knowledge of a witness or bystander, which in some cases are children, may improve response to an acute stroke event. Methods—We used a quasiexperimental pre-test post-test design to evaluate actionable stroke knowledge of 210 children aged 9 to 10 years in response to a single, 15-minute exposure […]
Clinical Trials
Sunday, March 2nd, 2014
STROKEAHA: January 14, 2014 Background and Purpose—Hemicraniectomy and Durotomy Upon Deterioration From Infarction-Related Swelling Trial (HeADDFIRST) was a randomized pilot study to obtain information necessary to design a Phase III trial to evaluate the benefit of surgical decompression for brain swelling from large supratentorial cerebral hemispheric infarction. Methods—All patients with stroke were screened for eligibility (age […]
Therapies
Sunday, March 2nd, 2014
STROKEAHA: February 25, 2014 Background and Purpose—Our objective was to study nationwide utilization trends of computed tomographic (CT) angiogram (CTA) and CT perfusion (CTP) in acute ischemic stroke and particularly in the context of use of reperfusion therapies. Methods—We reviewed the Premier Perspective Database for ischemic stroke–related hospitalizations of adult patients during a 5-year period, 2006 […]
Therapies
Sunday, March 2nd, 2014
AHA: February 20, 2014 Improving walking after stroke is one of the main goals of rehabilitation. Treadmill training, with or without body weight support, uses specialist equipment to assist walking practice. Objectives The objective of this review is to examine the effects of tread- mill training and body weight support, individually or in com- bination […]
Clinical Trials
Sunday, March 2nd, 2014
JACC: February 2014 In 1977, the World Health Organization (WHO) developed its first Model List of Essential Medicines to guide countries in the creation of national formularies and policies for access, quality, and use of essential medicines as part of achieving the right to health. In 2012, the WHO announced its goal of reducing the number […]
Therapies
Sunday, March 2nd, 2014
STROKEAHA: January 30, 2014 Background and Purpose—Apart from missing the approved time window of 4.5 hours, one frequent cause for withholding recombinant tissue plasminogen activator (rt-PA) treatment in patients with ischemic stroke is presentation with mild deficit on admission. We analyzed in a large cohort of patients whether rt-PA treatment is beneficial for this group of […]
Therapies
Sunday, March 2nd, 2014
STROKEAHA: January 14, 2014 Background and Purpose—A short duration (<24 hours) of antihypertensive therapy (AHT) after acute intracerebral hemorrhage (ICH) may be sufficient because active bleeding generally ceases within several hours. We aimed to determine the association between sequential systolic blood pressure (SBP) levels during AHT and outcomes in ICH patients. Methods—In 211 hyperacute ICH patients […]
News
Sunday, March 2nd, 2014
STROKEAHA: February 13, 2014 Background and Purpose—Many studies use medical record review for ascertaining outcomes. One large, longitudinal study, the Women’s Health Initiative (WHI), ascertains strokes using participant self-report and subsequent physician review of medical records. This is resource-intensive. Herein, we assess whether Medicare data can reliably assess stroke events in the WHI. Methods—Subjects were WHI […]
News
Sunday, March 2nd, 2014
Nejm: February 13, 2014 The postpartum state is associated with a substantially increased risk of thrombosis. It is uncertain to what extent this heightened risk persists beyond the conventionally defined 6-week postpartum period. Using claims data on all discharges from nonfederal emergency departments and acute care hospitals in California, we identified women who were hospitalized for […]
