Guidelines for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack

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AHA: May 1, 2014 A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association   The aim of this updated guideline is to provide comprehensive and timely evidence-based recommendations on the prevention of future stroke among survivors of ischemic stroke or transient ischemic attack. The guideline is addressed to all clinicians who manage […]

Evolution of ”The Guideline Advantage”: Lessons Learned From the Front Lines of Outpatient Performance Measurement

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AHA: 4/30/14 Heart disease, cancer, stroke, and diabetes mellitus collectively account for >1.37 million US deaths each year. Compounding the tragedy is the knowledge that many of those deaths could be avoided through better application of clinical guidelines related to primary and secondary prevention or dis- ease management. The combined control of blood pressure, lipids, and […]

Predisposing Factors Associated With Development of Persistent Compared With Paroxysmal Atrial Fibrillation

J Am Heart Assoc: May 1, 2014 Background Once atrial fibrillation (AF) progresses to sustained forms, adverse outcomes increase and treatment success rates decrease. Therefore, identification of risk factors predisposing to persistence of AF may have a significant impact on AF morbidity. Methods and Results We prospectively examined the differential associations between traditional, lifestyle, and biomarker AF risk […]

Historical Context and Detailed Translational Perspective on an Important Clinical Problem

CIRCRESAHA: 4/25/14 Circulation Research Compendium on Atrial Fibrillation: Atrial Fibrillation Compendium: Historical Context and Detailed Translational Perspective on an Important Clinical Problem The Clinical Profile and Pathophysiology of Atrial Fibrillation: Relationships Among Clinical Features, Epidemiology, and Mechanisms Emerging Directions in the Genetics of Atrial Fibrillation Cellular and Molecular Electrophysiology of Atrial Fibrillation Initiation, Maintenance and Progression Role […]

RACIAL DISPARITIES IN HOSPITALIZATIONS, PROCEDURAL TREATMENTS AND MORTALITY OF PATIENTS HOSPITALIZED WITH ATRIAL FIBRILLATION

Ishib: 4/9/14 Objectives: To explore racial differences in characteristics, procedural treatments, and mor- tality of hospitalized atrial fibrillation (AF) patients. Background: Despite a higher burden of AF risk factors, Black individuals have a lower prevalence of AF than their White counterparts. There is suggestion that AF may go undetected in minority groups, and there may be […]

Long-Term Follow-Up After Catheter Ablation of Paroxysmal Atrial Fibrillation

Circulation: Arrhythmia and Electrophysiology:  March 7, 2014 The Incidence of Recurrence and Progression of Atrial Fibrillation Background—Although catheter ablation (CA) is a standard treatment for atrial fibrillation (AF), its long-term efficacy remains unclear. This study aimed to elucidate the incidences of AF recurrence and of progression from paroxysmal to persistent AF, after CA, in patients […]

Variations in Cause and Management of Atrial Fibrillation in a Prospective Registry of 15 400 Emergency Department Patients in 46 Countries

CIRCULATIONAHA: January 24, 2014   Background—Atrial fibrillation (AF) is the most common sustained arrhythmia; however, little is known about patients in a primary care setting from high-, middle-, and low-income countries. Methods and Results—This prospective registry enrolled patients presenting to an emergency department with AF at 164 sites in 46 countries representing all inhabited continents. Patient […]

Extra-Virgin Olive Oil Consumption Reduces Risk of Atrial Fibrillation: The PREDIMED Trial

CIRCULATIONAHA: April 30, 2014 Background—The PREvención con DIeta MEDiterránea (PREDIMED) randomized primary prevention trial showed that a Mediterranean diet enriched with either extra-virgin olive oil or mixed nuts reduces incidence of stroke, myocardial infarction or cardiovascular mortality. We assessed the effect of these diets on the incidence of atrial fibrillation in the PREDIMED trial. Methods and Results—Participants were […]

Virtual Reality Exercise Improves Mobility After Stroke

STROKEAHA: April 24, 2014 Background and Purpose—Exercise using virtual reality (VR) has improved balance in adults with traumatic brain injury and community-dwelling older adults. Rigorous randomized studies regarding its efficacy, safety, and applicability with individuals after stroke are lacking. The purpose of this study was to determine whether an adjunct VR therapy improves balance, mobility, and […]

Relationship Between Time in Therapeutic Range and Comparative Treatment Effect of Rivaroxaban and Warfarin: Results From the ROCKET AF Trial

J Am Heart Assoc. 4/22/2014 Background Time in therapeutic range (TTR) is a standard quality measure of the use of warfarin. We assessed the relative effects of rivaroxaban versus warfarin at the level of trial center TTR (cTTR) since such analysis preserves randomized comparisons. Methods and Results TTR was calculated using the Rosendaal method, without exclusion of international […]

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