Atrial Fibrillation
Thursday, January 9th, 2014
CIRCULATIONAHA: December 17, 2013 Background—The global burden of atrial fibrillation (AF) is unknown. Methods and Results—We systematically reviewed population-based studies of AF published 1980-2010, from the 21 Global Burden of Disease (GBD) regions to estimate global/regional prevalence, incidence, as well as morbidity and mortality related to AF (DisModMR software). Of 377 potential studies identified, 184 met […]
Atrial Fibrillation
Thursday, January 9th, 2014
Dovepress: December 16, 2013 Abstract: Atrial fibrillation (AF) is the most common sustained arrhythmia and a major global public health problem due to its associated morbidity, including stroke and heart failure, diminished quality of life, and increased mortality. AF often presents initially in a paroxysmal form and may progress to a more sustained form over time. Evidence […]
Atrial Fibrillation
Thursday, January 9th, 2014
Eur Heart J: November 25, 2013 Aims Atrial fibrillation increases the risks of stroke, heart failure, and death, and anticoagulation therapy increases the risk of gastrointestinal haemorrhage. However, the relative event rates for these outcomes are not well described. We sought to define the risks of major clinical events in older adults after a new diagnosis of […]
Atrial Fibrillation
Saturday, December 14th, 2013
NEJM: 12/12/13 BACKGROUND The level of anticoagulation in response to a fixed-dose regimen of warfarin is difficult to predict during the initiation of therapy. We prospectively compared the effect of genotype-guided dosing with that of standard dosing on anticoagulation control in patients starting warfarin therapy. METHODS We conducted a multicenter, randomized, controlled trial involving patients with […]
Atrial Fibrillation
Saturday, December 14th, 2013
CIRCULATIONAHA: December 9, 2013 Background—Renal impairment increases the risk of stroke and bleeding in patients with atrial fibrillation. In the RE-LY trial dabigatran, with approximately 80% renal elimination, displayed superiority over warfarin for prevention of stroke and systemic embolism in the 150 mg dose, and significantly less major bleeding in the 110 mg dose in […]
Atrial Fibrillation
Saturday, December 14th, 2013
Neurology: December 6, 2013 Objective: To evaluate the safety and feasibility of percutaneous left atrial appendage occlusion (LAAO) in patients with atrial fibrillation (AF) and previous intracranial hemorrhage (ICH). Methods: In an explorative, prospective, single-center, observational study, LAAO was performed in patients with previous ICH and AF using the Amplatzer Cardiac Plug device. Risks of ischemic strokes and […]
Atrial Fibrillation
Saturday, December 14th, 2013
Ann Intern Med: 12/3/13 Background: Atrial fibrillation (AF) prediction models have unclear clinical utility given the absence of AF prevention therapies and the immutability of many risk factors. Premature atrial contractions (PACs) play a critical role in AF pathogenesis and may be modifiable. Objective: To investigate whether PAC count improves model performance for AF risk. Design: Prospective cohort […]
Atrial Fibrillation
Saturday, December 14th, 2013
Everyday Health: 11/27/13 If traditional treatments aren’t enough to control your symptoms living with atrial fibrillation, afib, and it means you’re not living the way you’d like, a clinical trial may provide the answer you need. “Patients are looking for highly experienced doctors, and most of those are very engaged in doing clinical trials. The clinical […]
Atrial Fibrillation
Saturday, December 14th, 2013
STROKEAHA: November 26, 2013 Background and Purpose—Preadmission oral anticoagulant treatment (OAT) has been linked with less severe stroke and a better outcome in patients with atrial fibrillation. However, the existing studies have methodological limitations and have, with one exception, not included hemorrhagic strokes. We performed a nationwide historic follow-up study using data from population-based healthcare registries […]
Atrial Fibrillation
Saturday, December 14th, 2013
Eur Heart J: November 25, 2013 Aims Atrial fibrillation increases the risks of stroke, heart failure, and death, and anticoagulation therapy increases the risk of gastrointestinal haemorrhage. However, the relative event rates for these outcomes are not well described. We sought to define the risks of major clinical events in older adults after a new diagnosis of […]
