Advances in Arrhythmia and Electrophysiology

Circulation: Arrhythmia and Electrophysiology: 10/1/13 Bachmann’s bundle (BB), also known as the interatrial bundle, is well recognized as a muscular bundle comprising of parallel aligned myocardial strands connecting the right and left atrial walls and is considered to be the main pathway of interatrial conduction.1 Disruption of the bundle’s structure causes interatrial conduction block (IAB),2 which is associated […]

Clinical and Population Studies

Arteriosclerosis, Thrombosis, and Vascular Biology: September 12, 2013 Objective—Atrial fibrillation (AF) and atherosclerotic vascular disease are closely entangled disorders and often coexist. Whether atherosclerosis predisposes to the development of AF has not been fully elucidated. Approach and Results—This study was performed within the framework of the Bruneck Study, a population-based survey with near-complete participation (932 of […]

Frequency Analysis of Atrial Action Potential Alternans

Circulation: Arrhythmia and Electrophysiology: August 31, 2013 Background—Few clinical indices identify the propensity of patients to atrial fibrillation (AF) when not in AF. Repolarization alternans has been shown to indicate AF vulnerability, but is limited in its sensitivity to detect changes in action potential (AP) duration (APD), which may be subtle. We hypothesized that spectral analysis […]

Incident Atrial Fibrillation Among Asians, Hispanics, Blacks, and Whites

CIRCULATIONAHA:  October 8, 2013 Background—As the association between atrial fibrillation (AF) and race has only been rigorously compared in population-based studies that dichotomized participants as White or Black, it is unclear whether White race confers elevated AF risk or Black race affords AF protection. Methods and Results—The Healthcare Cost and Utilization Project was used to […]

Discontinuing anticoagulation following successful atrial fibrillation ablation in patients with prior strokes

Springer: 10/8/13 This study was conducted to examine the outcomes in patients with prior stroke/transient ischemic attack (CVA/TIA) after atrial fibrillation (AF) ablation and the feasibility of discontinuing oral anticoagulation (OAC). Methods This study examined long-term outcomes following AF ablations in 108 patients with a history of prior thromboembolic CVA/TIA. Because of risks of OAC, we […]

Mitochondrial Dysfunction as an Arrhythmogenic Substrate

JACC: 10/1/13 A Translational Proof-of-Concept Study in Patients With Metabolic Syndrome in Whom Post-Operative Atrial Fibrillation Develops Objectives  This study sought to provide bedside evidence of the potential link between cardiac mitochondrial dysfunction and arrhythmia as reported in bench studies. Background  Atrial fibrillation (AF) is a frequent complication of cardiac surgery. Underlying mechanisms of post-operative atrial fibrillation (POAF) remain largely unknown. […]

Persistence of Atrial Septal Defect After Cryoballoon Ablation of Atrial Fibrillation

J Am Coll Cardiol: 10/1/13 Persistent iatrogenic atrial septal defect (iASD) after transseptal puncture for radiofrequency (RF) ablation of atrial fibrillation (AF) using 8-F sheaths has been reported at rates of 0 to 19% at medium-term follow-up, depending on the transseptal puncture technique, the follow-up interval, and whether transthoracic echocardiography (TTE) or transesophageal echocardiography was used for […]

Mitochondrial Dysfunction as an Arrhythmogenic Substrate

JACC: October 2013 A Translational Proof-of-Concept Study in Patients With Metabolic Syndrome in Whom Post-Operative Atrial Fibrillation Develops Objectives  This study sought to provide bedside evidence of the potential link between cardiac mitochondrial dysfunction and arrhythmia as reported in bench studies. Background  Atrial fibrillation (AF) is a frequent complication of cardiac surgery. Underlying mechanisms of post-operative atrial fibrillation (POAF) remain largely unknown. […]

Completeness of Reporting of Patient-Relevant Clinical Trial Outcomes: Comparison of Unpublished Clinical Study Reports with Publicly Available Data

PLOS: 10/8/13 Access to unpublished clinical study reports (CSRs) is currently being discussed as a means to allow unbiased evaluation of clinical research. The Institute for Quality and Efficiency in Health Care (IQWiG) routinely requests CSRs from manufacturers for its drug assessments. Our objective was to determine the information gain from CSRs compared to publicly available […]

Impact of Emergency Medical Services Stroke Routing Protocols on Primary Stroke Center Certification in Californi

STROKEAHA: October 8, 2013 Background and Purpose—Organized stroke systems of care include Primary Stroke Center (PSC) certification and preferential emergency medical services (EMS) routing of suspected patients with stroke to designated PSCs. Stroke EMS routing is not nationally governed; in California, routing is determined by county. EMS routing policies might provide an incentive for PSC accreditation. […]

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