Genetic Variants Related to Height and Risk of Atrial Fibrillation

Am. J. Epidemiol: June 18, 2014 Increased height is a known independent risk factor for atrial fibrillation (AF). However, whether genetic determinants of height influence risk is uncertain. In this candidate gene study, we examined the association of 209 height-associated single-nucleotide polymorphisms (SNPs) with incident AF in 3,309 persons of European descent from the Cardiovascular Health […]

Atrial Fibrillation, Stroke, and Anticoagulation in Medicare Beneficiaries: Trends by Age, Sex, and Race, 1992–2010

J Am Heart Assoc.: 6/3/14 Background We evaluated temporal trends in ischemic stroke and warfarin use among demographic subsets of the US Medicare population that are not well represented in randomized trials of warfarin for stroke prevention in nonvalvular atrial fibrillation (AF). Methods and Results One‐year cohorts of Medicare–primary payer patients (1992–2010) were created using the Medicare 5% […]

Pradaxa (dabigatran): Drug Safety Communication – Lower Risk for Stroke and Death, but Higher Risk for GI Bleeding Compared to Warfarin

FDA: 05/13/2014 AUDIENCE: Cardiology, Patient, Pulmonology, Internal Medicine, Orthopedics, Neurology ISSUE: The FDA recently completed a new study in Medicare patients comparing Pradaxa to warfarin, for risk of ischemic or clot-related stroke,  bleeding in the brain, major gastrointestinal (GI) bleeding, myocardial infarction (MI), and death. The new study included information from more than 134,000 Medicare […]

Top U.S. Heart Treatment Centers, Patient Group, Form Alliance to Improve Irregular Heartbeat Care

Sentara: 6/23/14 Atrial fibrillation affects more than 5 million and that number could triple over next three decades Overview Top U.S. heart centers implement a collaborative, multidisciplinary alliance to improve the treatment of patients with a type of irregular heartbeat called atrial fibrillation (Afib). Leading Afib patient advocacy group, StopAfib.org, is partnering with NAIAC to provide […]

Predictive Value of Newly Detected Atrial Fibrillation Paroxysms in Patients With Acute Ischemic Stroke, for Atrial Fibrillation After 90 Days

STROKEAHA: June 17, 2014 Background and Purpose—Extended cardiac monitoring immediately after acute ischemic stroke (AIS) increases paroxysmal atrial fibrillation (PAF) detection, but its reliability for detection or exclusion of longer term paroxysmal PAF is unknown. We evaluated the positive and negative predictive value (PPV and NPV) of AF detection early after AIS, for PAF confirmation 90 […]

Physical Activity, Obesity, Weight Change and Risk of Atrial Fibrillation: The Atherosclerosis Risk in Communities (ARIC) Study

CIRCEP: June 6, 2014 ackground—Physical activity (PA) has previously been suggested to attenuate the risk of atrial fibrillation (AF) conferred by excess body weight and weight gain. We prospectively examined the relationship between body size, weight change and level of PA in a biracial cohort of middle-aged men and women. Methods and Results—Baseline characteristics on risk […]

The Epidemic of Inadequate Biventricular Pacing in Patients With Persistent or Permanent Atrial Fibrillation and Its Association With Mortality

​CIRCEP: May 17, 2014 Background—We classified patients’ atrial fibrillation (AF), assessed its impact on biventricular pacing (BIVP%), and determined whether AF classification or BIVP% independently correlate with mortality in cardiac resynchronization therapy defibrillator patients. Methods and Results—Cardiac resynchronization therapy defibrillator patients were classified as permanent (daily mean AF burden ≥23 hours), persistent (≥7 consecutive days of […]

Temporal Relationship Between Subclinical Atrial Fibrillation and Embolic Events

CIRCULATIONAHA: March 14, 2014 Background—Among patients with implantable pacemakers and defibrillators, subclinical atrial fibrillation (SCAF) is associated with an increased risk of stroke; however, there is limited understanding of their temporal relationship. Methods and Results—The Asymptomatic Atrial Fibrillation and Stroke Evaluation in Pacemaker Patients and the Atrial Fibrillation Reduction Atrial Pacing Trial (ASSERT) enrolled 2580 pacemaker […]

Trends of Hospitalization for Atrial Fibrillation in the United States, 2000 Through 2010: Implications for Healthcare Planning

CIRCULATIONAHA: May 19, 2014 Background—Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. The associated morbidity and mortality makes AF a major public health burden. Hospitalizations account for the majority of the economic cost burden associated with AF. The main objective of this study is to examine trends of AF related hospitalizations in the US […]

The Epidemic of Inadequate Bi-Ventricular Pacing in Patients with Persistent or Permanent Atrial Fibrillation and Its Association with Mortality

CIRCEP: May 17, 2014 Background—We classified patients’ atrial fibrillation (AF), assessed its impact on bi-ventricular pacing (BIVP%), and determined if AF classification or BIVP% independently correlate with mortality in Cardiac Resynchronization Therapy Defibrillator (CRT-D) patients. Methods and Results—CRT-D patients were classified as Permanent (daily mean AF burden ≥23 hours), Persistent (≥7 consecutive days of AF ≥23 […]

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