Clinical TrialsSaturday, February 8th, 2014 BMC Health Services Research: January 17, 2014 Family caregivers provide invaluable support to stroke survivors during their recovery, rehabilitation, and community re-integration. Unfortunately, it is not standard clinical practice to prepare and support caregivers in this role and, as a result, many experience stress and poor health that can compromise stroke survivor recovery and threaten the sustainability of keeping the stroke survivor at home. We developed the Timing it Right Stroke Family Support Program (TIRSFSP) to guide the timing of delivering specific types of education and support to meet caregivers’ evolving needs. The objective of this multi-site randomized controlled trial is to determine if delivering the TIRSFSP across the stroke care continuum improves caregivers’ sense of being supported and emotional well-being. Read more NEWS Prevention and Health Services Delivery 2012–2013 Advances in Stroke: Population Studies 2013 Systematic Review of Health Disparities for Cardiovascular Diseases and Associated Factors among American Indian and Alaska Native Populations RESOURCES Search Publications in the Medicare Index Online Library Map Stroke Map Atrial Fibrillation CLINICAL TRIALS Randomized clinical trial of the timing it right stroke family support program: research protocol Mild Hypothermia After Intravenous Thrombolysis in Patients With Acute Stroke Three-dimensional, task-specific robot therapy of the arm after stroke: a multicentre, parallel-group randomised trial EMAIL SIGNUP SIGNUP to receive updates and information.

BMC Health Services Research: January 17, 2014 Family caregivers provide invaluable support to stroke survivors during their recovery, rehabilitation, and community re-integration. Unfortunately, it is not standard clinical practice to prepare and support caregivers in this role and, as a result, many experience stress and poor health that can compromise stroke survivor recovery and threaten the […]

Mild Hypothermia After Intravenous Thrombolysis in Patients With Acute Stroke

STROKEAHA: January 16, 2014 Background and Purpose—Hypothermia improves outcome in resuscitated patients and newborns with hypoxic brain injury. We studied the safety and feasibility of mild hypothermia in awake patients with stroke after intravenous thrombolysis. Methods—Patients were randomized 1:1 to mild hypothermia (35°C) or to standard stroke unit care within 6 hours of symptom onset. Hypothermia […]

Three-dimensional, task-specific robot therapy of the arm after stroke: a multicentre, parallel-group randomised trial

The Lancet Neurology: February 2014 Background Arm hemiparesis secondary to stroke is common and disabling. We aimed to assess whether robotic training of an affected arm with ARMin—an exoskeleton robot that allows task-specific training in three dimensions—reduces motor impairment more effectively than does conventional therapy. Methods In a prospective, multicentre, parallel-group randomised trial, we enrolled patients […]

Effect Size Measures and Their Relationships in Stroke Studies

STROKEAHA: December 26, 2013 Many articles in Stroke have considered good statistical practice for adequate planning and high-power analysis for stroke trials. They have discussed which test may be adequate and powerful, proposals for an effect size measure, and proposals for defining number needed to treat (NNT) based on an ordinal scale (see online-only Data Supplement for citations). […]

Stem Cells as an Emerging Paradigm in Stroke 3

STROKEAHA: December 24, 2013 Cell-based therapy continues to grow as a new field to explore investigational treatments for stroke. Leaders from academia and industry convened an inaugural meeting in 2007 with members of the National Institutes of Health and Food and Drug Administration (FDA) to generate consensus-based guidelines on the development of cell therapies for stroke, […]

Health service management study for stroke: A randomized controlled trial to evaluate two models of stroke care

Wiley: JAN 3, 2014 Background The most effective and efficient model for providing organized stroke care remains uncertain. This study aimed to compare the effect of two models in a randomized controlled trial. Methods Patients with acute stroke were randomized on day one of admission to combined, co-located acute/rehabilitation stroke care or traditionally separated acute/rehabilitation stroke […]

ASA failure: Does the combination ASA/clopidogrel confer better long-term vascular protection?

Neurology: January 2, 2014 Objective: To assess whether adding clopidogrel to acetylsalicylic acid (ASA) has a long-term protective vascular effect in patients with lacunar stroke while taking ASA. Methods: Post hoc analysis of 838 patients with ASA failure and recent lacunar stroke from the Secondary Prevention of Small Subcortical Strokes Trial (SPS3) cohort randomly allocated to aspirin (325 […]

A Randomised Controlled Trial of Catheter Ablation versus Medical Treatment of Atrial Fibrillation in Heart Failure (THE CAMTAF TRIAL)

CIRCEP: January 1, 2014 Background—Restoring sinus rhythm in patients with heart failure (HF) and atrial fibrillation (AF) may improve left ventricular (LV) function and HF symptoms. We sought to compare the impact of a catheter ablation strategy with that of a medical rate control strategy in patients with persistent AF and HF. Methods and Results—Patients with […]

Subscribe/Learn More > Clinical Research | December 2013 Factors Associated with Major Bleeding Events: Insights from the Rivaroxaban Once-daily oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF) ONLINE FIRST

JACC: December 2013 Objectives  – To report additional safety results from the Rivaroxaban Once-daily oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF). Background  ROCKET AF demonstrated similar risks of stroke/systemic embolism and major/nonmajor clinically relevant bleeding (principal safety endpoint) with rivaroxaban and warfarin. […]

Effect of Remote Ischemic Preconditioning on Platelet Activation and Reactivity Induced by Ablation for Atrial Fibrillation

CIRCULATIONAHA: November 25, 2013 Background—Radiofrequency ablation of atrial fibrillation has been associated with some risk of thromboembolic events. Previous studies showed that preventive short episodes of forearm ischemia (remote ischemic preconditioning [IPC]) reduce exercise-induced platelet reactivity. In this study, we assessed whether remote IPC has any effect on platelet activation induced by radiofrequency ablation of atrial […]

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