Atrial Fibrillation
Thursday, August 7th, 2014
J Am Coll Cardiol.: August 2014 Background Transcatheter left atrial appendage (LAA) ligation may represent an alternative to oral anticoagulation for stroke prevention in atrial fibrillation. Objectives This study sought to assess the early safety and efficacy of transcatheter ligation of the LAA for stroke prevention in atrial fibrillation. Methods This was a retrospective, multicenter study of consecutive patients undergoing LAA […]
Atrial Fibrillation
Thursday, August 7th, 2014
Heart rhythm journal: August 04, 2014 Background Traditional mapping of atrial fibrillation (AF) is limited by changing electrogram morphologies and variable cycle lengths. Objective We tested the hypothesis that morphology recurrence plot analysis would identify sites of stable and repeatable electrogram morphology patterns. Methods AF electrograms recorded from left atrial (LA) and right atrial (RA) sites […]
Atrial Fibrillation
Thursday, August 7th, 2014
Heart rhythm journal: August 04, 2014 Background The risk of acute myocardial infarction (AMI) in patients with atrial fibrillation (AF) having a CHA2DS2-VASc score of 0 (for males) or 1 (for females) has not been previously investigated. Objective The goal of the present study was to compare the risk of AMI among AF and non-AF subjects […]
Atrial Fibrillation
Thursday, August 7th, 2014
JAMA: August 2014 Despite the introduction of several novel oral anticoagulants, warfarin remains the most widely used anticoagulation agent worldwide. Physicians have extensive experience with warfarin, it is inexpensive, its effects are easily reversible, and its activity can be monitored with a simple blood test. However, warfarin has a narrow therapeutic index and requires active […]
Atrial Fibrillation
Thursday, August 7th, 2014
CIRCGENETICS: August 1, 2014 Background—Genome-wide association studies (GWAS) have shown that the common single nucleotide polymorphism (SNP) rs6800541 located in SCN10A, encoding the voltage-gated Nav1.8 sodium channel, is associated with PR−interval prolongation and atrial fibrillation (AF). SNP rs6800541 is in high linkage disequilibrium with the non-synonymous variant in SCN10A, rs6795970 (V1073A, r2=0.933). We aim to determine whether common […]
Clinical Trials
Thursday, August 7th, 2014
J Am Coll Cardiol.: 6, August 2014 Background At the end of 2 previous trials, an excess of stroke and bleeding was observed in patients with AF randomized to a new oral anticoagulant (NOAC) who transitioned to a vitamin K antagonist (VKA). Objectives The ENGAGE AF–TIMI 48 (Effective Anticoagulation with Factor Xa Next Generation in Atrial Fibrillation—Thrombolysis in Myocardial Infarction […]
Clinical Trials
Thursday, August 7th, 2014
The Lancet: 6 August 2014 Background Alteplase is effective for treatment of acute ischaemic stroke but debate continues about its use after longer times since stroke onset, in older patients, and among patients who have had the least or most severe strokes. We assessed the role of these factors in affecting good stroke outcome in […]
Clinical Trials
Thursday, August 7th, 2014
STROKEAHA: July 31, 2014 Background and Purpose—Adverse events (AE) in trial populations present a major burden to researchers and patients, yet most events are unrelated to investigational treatment. We aimed to develop a coherent list of expected AEs, whose incidence can be predicted by patient characteristics that will inform future trials and perhaps general poststroke care. […]
Clinical Trials
Thursday, August 7th, 2014
AHA: July 31, 2014 Background and Purpose—We aimed at comparing the long-term benefit–risk balance of carotid stenting versus endarterectomy for symptomatic carotid stenosis. Methods—Long-term follow-up study of patients included in Endarterectomy Versus Angioplasty in Patients With Symptomatic Severe Carotid Stenosis (EVA-3S), a randomized, controlled trial of carotid stenting versus endarterectomy in 527 patients with recently […]
Therapies
Thursday, August 7th, 2014
Neurolog: August 6, 2014 Objective: We sought to identify current US hospital practices for feeding tube placement in ischemic stroke. Methods: In a retrospective observational study, we examined the frequency of feeding tube placement among hospitals in the Nationwide Inpatient Sample with ≥30 adult ischemic stroke admissions annually with length of stay greater than 3 days. We examined […]
